N-苄基-2-氯-9H-嘌呤-6-胺合成路线 （共 19 条）
反应条件
triethylamine in butan-1-ol T=110°C; 3 h; Large scale reaction;
参考文献
CASE WESTERN RESERVE UNIVERSITY; THE CURATORS OF THE UNIVERSITY OF MISSOURI; REDDY, Parkash, V.; NAIR, Nanditha, G.; SMITH, Mark, A.; KUDO, Wataru
Patent: WO2012/51296 A2, 2012 ;
Location in patent: Page/Page column 40 ;
WO 2012/051296 A2
反应条件
in Sec-butyl alcohol T=60°C;
参考文献
Mallari, Jeremy P.; Shelat, Anang A.; Obrien, Terri; Caffrey, Conor R.; Kosinski, Aaron; Connelly, Michele; Harbut, Michael; Greenbaum, Doron; McKerrow, James H.; Guy, R. Kiplin
Journal of Medicinal Chemistry, 2008 , vol. 51, # 3 p. 545 - 552
反应条件
1: 66.2 percent / aq. NaNO2, aq. HOAc / H2O / 2 h / 70 - 80 °C 2: 39.9 percent / POCl3, NEt3 / 3 h / Heating 3: 80.5 percent / butan-1-ol / 5 h / 100 °C View Scheme
参考文献
Oh, Chang-Hyun; Lee, Su-Chul; Lee, Ki-Soo; Woo, Eun-Rhan; Hong, Chang Yong; Yang, Boem-Seok; Baek, Dae Jin; Cho, Jung-Hyuck
Archiv der Pharmazie, 1999 , vol. 332, # 6 p. 187 - 190
反应条件
1: 39.9 percent / POCl3, NEt3 / 3 h / Heating 2: 80.5 percent / butan-1-ol / 5 h / 100 °C View Scheme
参考文献
Oh, Chang-Hyun; Lee, Su-Chul; Lee, Ki-Soo; Woo, Eun-Rhan; Hong, Chang Yong; Yang, Boem-Seok; Baek, Dae Jin; Cho, Jung-Hyuck
Archiv der Pharmazie, 1999 , vol. 332, # 6 p. 187 - 190
反应条件
1: water / 4.5 h / 70 °C 2: water; sodium hydroxide / 3 h / 20 °C 3: hydrogenchloride; zinc(II) chloride; sodium nitrite / water / 1 h / -5 - 5 °C 4: isopropyl alcohol / 3.5 h / 82 °C View Scheme
参考文献
Steklov, Mikhail Yu.; Tararov, Vitali I.; Romanov, Georgy A.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 7-8 p. 503 - 511
反应条件
1: water; sodium hydroxide / 3 h / 20 °C 2: hydrogenchloride; zinc(II) chloride; sodium nitrite / water / 1 h / -5 - 5 °C 3: isopropyl alcohol / 3.5 h / 82 °C View Scheme
参考文献
Steklov, Mikhail Yu.; Tararov, Vitali I.; Romanov, Georgy A.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 7-8 p. 503 - 511
反应条件
1: trichlorophosphate / 1,2-dichloro-ethane / 8 h / 80 °C 2: water / 4.5 h / 70 °C 3: water; sodium hydroxide / 3 h / 20 °C 4: hydrogenchloride; zinc(II) chloride; sodium nitrite / water / 1 h / -5 - 5 °C 5: isopropyl alcohol / 3.5 h / 82 °C View Scheme
参考文献
Steklov, Mikhail Yu.; Tararov, Vitali I.; Romanov, Georgy A.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 7-8 p. 503 - 511
反应条件
1: hydrogenchloride; zinc(II) chloride; sodium nitrite / water / 1 h / -5 - 5 °C 2: isopropyl alcohol / 3.5 h / 82 °C View Scheme
参考文献
Steklov, Mikhail Yu.; Tararov, Vitali I.; Romanov, Georgy A.; Mikhailov, Sergey N.
Nucleosides, Nucleotides and Nucleic Acids, 2011 , vol. 30, # 7-8 p. 503 - 511
参考文献
Geng, Bolin; Breault, Gloria; Comita-Prevoir, Janelle; Petrichko, Randy; Eyermann, Charles; Lundqvist, Tomas; Doig, Peter; Gorseth, Elise; Noonan, Brian
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 15 p. 4368 - 4372
反应条件
1: 85 percent / K2CO3 / dimethylsulfoxide 2: 69 percent / 3 h / 155 - 160 °C View Scheme
参考文献
Havlicek, Libor; Hanus, Jan; Vesely, Jaroslav; Leclerc, Sophie; Meijer, Laurent; Shaw, Gordon; Strnad, Miroslav
Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 408 - 412
