5,6-二氢-11H-苯并(5,6)环庚并(1,2-b)吡啶-11-酮合成路线 （共 9 条）
反应条件
1: tetrahydrofuran / -40 °C 2: H2SO4 View Scheme
参考文献
Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
反应条件
manganese(IV) oxide in benzene
T=25°C; 12 h; Inert atmosphere;
参考文献
Naredla, Rajasekhar Reddy; Klumpp, Douglas A.
Tetrahedron, 2013 , vol. 69, # 9 p. 2137 - 2141
参考文献
Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
反应条件
1: 1.) n-BuLi / 1.) THF, -40 deg C
2: POCl3 / Heating
3: PPA / Heating
View Scheme
参考文献
Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
反应条件
1: 1.) n-BuLi / 1.) THF, -40 deg C
2: POCl3 / Heating
3: PPA / Heating
View Scheme
参考文献
Piwinski, John J.; Wong, Jesse K.; Green, Michael J.; Ganguly, Ashit K.; Billah, M. Motasim; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 457 - 461
反应条件
1.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 2 h / 25 °C / |Inert atmosphere
1.2: |Inert atmosphere
2.1: manganese(IV) oxide / benzene / 12 h / 25 °C / |Inert atmosphere
View Scheme
参考文献
Naredla, Rajasekhar Reddy; Klumpp, Douglas A.
Tetrahedron, 2013 , vol. 69, # 9 p. 2137 - 2141
反应条件
1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / |Inert atmosphere; |Reflux
2.1: 5 palladium on charcoal; hydrogen / ethyl acetate / 2 h / 10343.2 Torr / |Autoclave
3.1: manganese(IV) oxide / benzene / 12 h / 20 °C / |Inert atmosphere
4.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 2 h / 25 °C / |Inert atmosphere
4.2: |Inert atmosphere
5.1: manganese(IV) oxide / benzene / 12 h / 25 °C / |Inert atmosphere
View Scheme
参考文献
Naredla, Rajasekhar Reddy; Klumpp, Douglas A.
Tetrahedron, 2013 , vol. 69, # 9 p. 2137 - 2141
反应条件
1.1: 5 palladium on charcoal; hydrogen / ethyl acetate / 2 h / 10343.2 Torr / |Autoclave
2.1: manganese(IV) oxide / benzene / 12 h / 20 °C / |Inert atmosphere
3.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 2 h / 25 °C / |Inert atmosphere
3.2: |Inert atmosphere
4.1: manganese(IV) oxide / benzene / 12 h / 25 °C / |Inert atmosphere
View Scheme
参考文献
Naredla, Rajasekhar Reddy; Klumpp, Douglas A.
Tetrahedron, 2013 , vol. 69, # 9 p. 2137 - 2141
反应条件
1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / |Inert atmosphere; |Reflux
2.1: 5 palladium on charcoal; hydrogen / ethyl acetate / 2 h / 10343.2 Torr / |Autoclave
3.1: manganese(IV) oxide / benzene / 12 h / 20 °C / |Inert atmosphere
4.1: trifluoroacetic acid; trifluorormethanesulfonic acid / 2 h / 25 °C / |Inert atmosphere
4.2: |Inert atmosphere
5.1: manganese(IV) oxide / benzene / 12 h / 25 °C / |Inert atmosphere
View Scheme
参考文献
Naredla, Rajasekhar Reddy; Klumpp, Douglas A.
Tetrahedron, 2013 , vol. 69, # 9 p. 2137 - 2141
