乙基 6-甲基吡啶-2-羧酸酯合成路线 （共 11 条）
参考文献
Housey, Gerad M.
Patent: US2010/16298 A1, 2010 ;
Location in patent: Page/Page column 194 ;
反应条件
hydrogenchloride; hydrogen; platinum(IV) oxide in water P=760 Torr; 16 h; also other pyridine esters; var. catalysts and conditions; Product distribution;
参考文献
Bolos; Gubert; Anglada; Perez; Sacristan; Ortiz
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1493 - 1496
参考文献
CHEMOCENTRYX
Patent: WO2005/113513 A2, 2005 ;
Location in patent: Page/Page column 178 ;
WO 2005/113513 A2
反应条件
1: With selenium(IV) oxide; acetic acid 48 h; Heating / reflux; 2: With sodium hydrogencarbonate in water pH=6;
参考文献
Housey, Gerad M.
Patent: US2010/16298 A1, 2010 ;
Location in patent: Page/Page column 194 ;
反应条件
2: LiAlH4; diethyl ether View Scheme
参考文献
Nikitskaja et al.
Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 161,166; engl. Ausg. S. 161, 165
反应条件
1: neat (no solvent) / 48 h / |Inert atmosphere; |Schlenk technique; |Reflux 2: tetrahydrofuran / 15 h / 50 °C / |Inert atmosphere; |Schlenk technique View Scheme
参考文献
Wang, Daoyong; Zavalij, Peter Y.; Vedernikov, Andrei N.
Organometallics, 2013 , vol. 32, # 17 p. 4882 - 4891
反应条件
sodium ethanolate in toluene
2.5 h; Reflux;
参考文献
Skolnick, Phil; Epstein, Joseph William
Patent: US2005/245517 A1, 2005 ;
Location in patent: Page/Page column 11-12 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane
T=84°C; Heating / reflux;
参考文献
Gillespie, Paul; Goodnow, Robert Alan; Tilley, Jefferson Wright
Patent: US2006/122256 A1, 2006 ;
Location in patent: Page/Page column 22 ;
US 20060122256 A1
反应条件
in neat (no solvent)
48 h; Inert atmosphereSchlenk techniqueReflux;
参考文献
Wang, Daoyong; Zavalij, Peter Y.; Vedernikov, Andrei N.
Organometallics, 2013 , vol. 32, # 17 p. 4882 - 4891
反应条件
1: 2-bromo-4-methyl-pyridine With sodium hexamethyldisilazane in tetrahydrofuran
T=-30°C; 1 h;
2: 6-methyl-2-picolinic acid ethyl ester in tetrahydrofuran
T=-30 - 20°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/13135 A1, 2004 ;
Location in patent: Page 54 ;
WO 2004/013135 A1
