(R)-(-)-2-羟基-2-苯基丙酸合成路线 （共 34 条）
反应条件
1: 98 percent / tetrahydrofuran / -78 - 20 °C 2: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C 3: silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling View Scheme
参考文献
Chacon-Garcia, Luis; Lagunas-Rivera, Selene; Perez-Estrada, Salvador; Vargas-Diaz, M. Elena; Joseph-Nathan, Pedro; Tamariz, Joaquin; Zepeda, L. Gerardo
Tetrahedron Letters, 2004 , vol. 45, # 10 p. 2141 - 2145
反应条件
silver(l) oxide in tetrahydrofuran; water 0.25 h; cooling;
参考文献
Perez-Estrada, Salvador; Lagunas-Rivera, Selene; Vargas-Diaz, Maria Elena; Velazquez-Ponce, Pedro; Joseph-Nathan, Pedro; Zepeda, L. Gerardo
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1837 - 1843
反应条件
1: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C 2: silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling View Scheme
参考文献
Perez-Estrada, Salvador; Lagunas-Rivera, Selene; Vargas-Diaz, Maria Elena; Velazquez-Ponce, Pedro; Joseph-Nathan, Pedro; Zepeda, L. Gerardo
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1837 - 1843
反应条件
1: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C 2: silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling View Scheme
参考文献
Perez-Estrada, Salvador; Lagunas-Rivera, Selene; Vargas-Diaz, Maria Elena; Velazquez-Ponce, Pedro; Joseph-Nathan, Pedro; Zepeda, L. Gerardo
Tetrahedron Asymmetry, 2005 , vol. 16, # 10 p. 1837 - 1843
反应条件
1: toluene; tetrahydrofuran; benzene 2: 62 percent / H2SO4 / H2O / 0.5 h / 90 °C View Scheme
参考文献
Pansare, Sunil V.; Ravi, R. Gnana
Tetrahedron, 1998 , vol. 54, # 48 p. 14549 - 14564
反应条件
1: 1) LiN(i-Pr)2, HMPT / 1) -70 deg C, THF, 2) -70 to 0 deg C, 10 min 2: KOH / H2O; methanol / 0.17 h / 60 °C / e.e.: 85percent View Scheme
参考文献
Frater, Gy.; Mueller, U.; Guenther, W.
Tetrahedron Letters, 1981 , vol. 22, # 42 p. 4221 - 4224
反应条件
1: 81 percent / 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride, 4-dimethylaminopyridine / CH2Cl2 / 1 h / Heating 2: diethyl ether / 1 h / -78 °C 3: 93 percent / 20percent ethanolic KOH / ethanol / 3 h / Heating View Scheme
参考文献
Fuji; Tanaka; Ahn; Mizuchi
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 4 p. 957 - 959
反应条件
1: diethyl ether / 1 h / -78 °C 2: 93 percent / 20percent ethanolic KOH / ethanol / 3 h / Heating View Scheme
参考文献
Fuji; Tanaka; Ahn; Mizuchi
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 4 p. 957 - 959
反应条件
1: 97 percent / pyridine / benzene / 3 h / Ambient temperature View Scheme
参考文献
Hassine, B. Ben; Gorsane, M.; Geerts-Evrard, F.; Pecher, J.; Martin, R. H.; Castelet, D.
Bulletin des Societes Chimiques Belges, 1986 , vol. 95, p. 557 - 566
反应条件
1.1: lithium diisopropylamine / hexane; diethyl ether / 0.5 h / -78 °C 1.2: hexane; diethyl ether / 2 h / -78 °C 2.1: aq. KOH / methanol / 3 h / Heating View Scheme
参考文献
Han, Xiang-Yu; Liu, He; Liu, Chun-He; Wu, Bo; Zhong, Bo-Hua; Liu, Ke-Liang
Journal of Chemical Research, 2004 , # 12 p. 816 - 817
