(R)-(-)-α-甲氧基苯乙酸合成路线 （共 47 条）
反应条件
1: LiAlH4 / tetrahydrofuran / 0 °C 2: periodic acid / RuCl3 View Scheme
参考文献
Wei, Han-Xun; Willis, Steven; Li, Guigen
Tetrahedron Letters, 1998 , vol. 39, # 45 p. 8203 - 8206
反应条件
1: Ag2O / acetonitrile / Heating 2: LiAlH4 / tetrahydrofuran / 0 °C 3: periodic acid / RuCl3 View Scheme
参考文献
Wei, Han-Xun; Willis, Steven; Li, Guigen
Tetrahedron Letters, 1998 , vol. 39, # 45 p. 8203 - 8206
反应条件
1: 99 percent / Et2O*BF3 / 0.17 h / -30 °C 2: 90 percent / NaIO4 / RuCl3*3H2O / acetonitrile; CCl4; H2O / 2 h / Ambient temperature View Scheme
参考文献
Takano, Seiichi; Yanase, Masashi; Ogasawara, Kunio
Synthesis, 1989 , # 1 p. 39 - 40
反应条件
(S)-HBTM; N-ethyl-N,N-diisopropylamine in toluene T=0°C; 24 h; optical yield given as percent eeenantioselective reaction;
参考文献
Yang, Xing; Birman, Vladimir B.
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 14-15 p. 2301 - 2304
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 48 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Wang, Pei-Yun; Wu, Chia-Hui; Ciou, Jyun-Fen; Wu, An-Chi; Tsai, Shau-Wei
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 66, # 1-2 p. 113 - 119
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 1.3 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Wang, Pei-Yun; Wu, Chia-Hui; Ciou, Jyun-Fen; Wu, An-Chi; Tsai, Shau-Wei
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 66, # 1-2 p. 113 - 119
参考文献
Barth,G. et al.
Journal of the American Chemical Society, 1970 , vol. 92, p. 875 - 886
反应条件
tert.-butyl lithium; (4S)-2,2'-(1-Ethylpropylidene)bislt;4-(1-methylethyl)-4,5-dihydrooxazolegt; in hexane T=-110 - -78°C; Carboxylation; 5 h; Title compound not separated from byproducts;
参考文献
Komine, Nobuyuki; Wang, Lan-Fang; Tomooka, Katsuhiko; Nakai, Takeshi
Tetrahedron Letters, 1999 , vol. 40, # 37 p. 6809 - 6812
反应条件
1: 47 percent / NaOH / H2O / 3 h / 45 °C View Scheme
参考文献
Barth,G. et al.
Journal of the American Chemical Society, 1970 , vol. 92, p. 875 - 886
反应条件
1: aqueous NaIO4 2: Ag2O View Scheme
参考文献
Bonner
Journal of the American Chemical Society, 1951 , vol. 73, p. 3126,3130
