1-甲基-3-苯基-1H-[1,2,4]噻唑合成路线 （共 14 条）
反应条件
anhydrous potassium sulfate; potassium hydrogensulfate; oxone; sodium hydrogencarbonate in water; acetone
T=20°C; Oxidation; rearrangement; elimination; 42 h;
参考文献
Collins, David J.; Hughes, Timothy C.; Johnson, Wynona M.
Australian Journal of Chemistry, 1999 , vol. 52, # 10 p. 971 - 975
反应条件
potassium hydroxide in methanol
2 h; Heating;
参考文献
Fliege, Werner; Grashey, Rudolf; Huisgen, Rolf
Chemische Berichte, 1984 , vol. 117, # 3 p. 1194 - 1214
参考文献
Metz, Hans-Joachim; Neunhoeffer, Hans
Chemische Berichte, 1982 , vol. 115, # 8 p. 2807 - 2818
反应条件
1: 93 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH2Cl2 / 20 °C
2: 84 percent / 2KHSO5*KHSO4*K2SO4; NaHCO3 / H2O; acetone / 42 h / 20 °C
View Scheme
参考文献
Collins, David J.; Hughes, Timothy C.; Johnson, Wynona M.
Australian Journal of Chemistry, 1999 , vol. 52, # 10 p. 971 - 975
反应条件
1: 63 percent / Br2 / acetic acid / 2 h / Ambient temperature
2: 97 percent / Et3N / benzene / 1 h / Heating
3: 78 percent / 20 percent KOH / methanol / 2 h / Heating
View Scheme
参考文献
Fliege, Werner; Grashey, Rudolf; Huisgen, Rolf
Chemische Berichte, 1984 , vol. 117, # 3 p. 1194 - 1214
反应条件
1: 97 percent / Et3N / benzene / 1 h / Heating
2: 78 percent / 20 percent KOH / methanol / 2 h / Heating
View Scheme
参考文献
Fliege, Werner; Grashey, Rudolf; Huisgen, Rolf
Chemische Berichte, 1984 , vol. 117, # 3 p. 1194 - 1214
反应条件
1: 95 percent / 8 M NH3 / methanol / 24 h / Ambient temperature
2: 66 percent / methanol
View Scheme
参考文献
Metz, Hans-Joachim; Neunhoeffer, Hans
Chemische Berichte, 1982 , vol. 115, # 8 p. 2807 - 2818
反应条件
1: 160 °C
2: methanol; diethyl ether
View Scheme
参考文献
Atkinson; Polya
Journal of the Chemical Society, 1954 , p. 3319,3322
反应条件
1: 84 percent / methanol / 24 h
2: 93 percent / 0.08 h / 180 °C
3: 66 percent / methanol
View Scheme
参考文献
Metz, Hans-Joachim; Neunhoeffer, Hans
Chemische Berichte, 1982 , vol. 115, # 8 p. 2807 - 2818
反应条件
1: 93 percent / 0.08 h / 180 °C
2: 66 percent / methanol
View Scheme
参考文献
Metz, Hans-Joachim; Neunhoeffer, Hans
Chemische Berichte, 1982 , vol. 115, # 8 p. 2807 - 2818
