1-苄基-4-甲基哌啶-4-醇合成路线 （共 13 条）
反应条件
1: AlCl3, aluminium chloride / 62 h / 20 - 100 °C
2: ammonium formate / palladium 10 on activated carbon / water; industrial methylated spirit / 0.5 h / Reflux; Inert atmosphere
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参考文献
THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert
Patent: WO2011/33255 A1, 2011 ;
WO 2011/033255 A1
反应条件
1: With AlCl3, aluminium chloride
Reflux;
2: With water; sodium hydroxide
Cooling with ice;
3: With 1-chloroethyl chlorocarbonate in methanol
0.166667 h; Reflux;
参考文献
THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert
Patent: WO2011/33255 A1, 2011 ;
Location in patent: Page/Page column 76; 77 ;
WO 2011/033255 A1
反应条件
1: With hydrogen; palladium 10 on activated carbon in methanol
P=1810.07 Torr; 18 h;
2: With hydrogenchloride in 1,4-dioxane; methanol
参考文献
EXELIXIS, INC.; RICE, Kenneth
Patent: WO2012/71509 A2, 2012 ;
Location in patent: Page/Page column 154 ;
WO 2012/071509 A2
