N-[4-[[(5-甲基-1,3,4-噻二唑-2-基)氨基]磺酰基]苯基]乙酰胺合成路线 （共 6 条）
反应条件
1: With hydrogenchloride in water 0.5 h; Reflux; 2: With sodium carbonate in water
参考文献
Ahad, Ali Md.; Zuohe, Song; Du-Cuny, Lei; Moses, Sylvestor A.; Zhou, Li Li; Zhang, Shuxing; Powis, Garth; Meuillet, Emmanuelle J.; Mash, Eugene A.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 2046 - 2054
反应条件
pyridine
T=0 - 95°C;
参考文献
Ahad, Ali Md.; Zuohe, Song; Du-Cuny, Lei; Moses, Sylvestor A.; Zhou, Li Li; Zhang, Shuxing; Powis, Garth; Meuillet, Emmanuelle J.; Mash, Eugene A.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 6 p. 2046 - 2054
反应条件
in pyridine
T=20°C; 2 h;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHARPE, Arlene, H.; BUTTE, Manish, J.; OYAMA, Shinji
Patent: WO2011/82400 A2, 2011 ;
Location in patent: Page/Page column 52 ;
反应条件
1: dichloromethane; pyridine / 2 h / 20 °C
2: hydrogenchloride / iron / ethanol; water / 3 h / Reflux
3: pyridine / 2 h / 20 °C
View Scheme
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHARPE, Arlene, H.; BUTTE, Manish, J.; OYAMA, Shinji
Patent: WO2011/82400 A2, 2011 ;
反应条件
1: hydrogenchloride / iron / ethanol; water / 3 h / Reflux
2: pyridine / 2 h / 20 °C
View Scheme
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHARPE, Arlene, H.; BUTTE, Manish, J.; OYAMA, Shinji
Patent: WO2011/82400 A2, 2011 ;
参考文献
Koizumi,T. et al.
Chemical and Pharmaceutical Bulletin, 1964 , vol. 12, p. 421 - 427
