(R)-(+)-2-(Boc-氨基)-1,4-丁二醇合成路线 (共 6 条)
反应条件
sodium tetrahydroborate in ethanol T=0°C; 1.5 h; Heating / reflux;
参考文献
CYTOKINETICS, INC.
Patent: WO2007/56056 A2, 2007 ;
Location in patent: Page/Page column 76 ;
反应条件
sodium tetrahydroborate in tetrahydrofuran T=1°C; Heating;
参考文献
Martinkova, Miroslava; Gonda, Jozef; Dzoganova, Martina
Collection of Czechoslovak Chemical Communications, 2006 , vol. 71, # 8 p. 1199 - 1210
反应条件
sodium tetrahydroborate; calcium chloride in ethanol T=0°C; 2 h;
参考文献
Moon, Sung-Hwan; Lee, Sujin
Synthetic Communications, 1998 , vol. 28, # 21 p. 3919 - 3926
反应条件
1: Et3N / CH2Cl2 / 1 h / -10 - 0 °C 2: aq. NH4OH / acetonitrile / 48 h / Ambient temperature View Scheme
参考文献
Moon, Sung-Hwan; Lee, Sujin
Synthetic Communications, 1998 , vol. 28, # 21 p. 3919 - 3926
反应条件
1: Et3N / CH2Cl2 / 1 h / -10 - 0 °C 2: CH2Cl2 / 24 h / Heating View Scheme
参考文献
Moon, Sung-Hwan; Lee, Sujin
Synthetic Communications, 1998 , vol. 28, # 21 p. 3919 - 3926
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C; 24 h;
参考文献
CYTOKINETICS, INC.
Patent: WO2007/56056 A2, 2007 ;
Location in patent: Page/Page column 77 ;