1-(2-羟基-4-碘苯基)乙酮合成路线 （共 7 条）
反应条件
aluminium trichloride in chlorobenzene
T=140°C; Fries rearrangement; 90 h;
参考文献
ROWETT RESEARCH INSTITUTE
Patent: WO2004/7475 A1, 2004 ;
Location in patent: Page 34-35 ;
反应条件
1: 97 percent / triethylamine; 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 2 h
2: 69 percent / AlCl3 / chlorobenzene / 90 h / 140 °C
View Scheme
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
2: With AlCl3, aluminium chloride in chlorobenzene
参考文献
ANTOXIS LIMITED; McPhail, Donald Barton; Cook, Graeme James; Hartley, Richard Charles
Patent: US2013/267586 A1, 2013 ;
Location in patent: Paragraph 0189 ;
反应条件
aluminium trichloride; nitrobenzene
参考文献
Chen; Chang
Taiwan Yaoxue Zazhi, 1952 , vol. 4, p. 38
Journal of the Chemical Society, 1958 , p. 146,149
反应条件
(i) AlCl3, (ii) aq. NaOH; Multistep reaction;
参考文献
Kobayashi,S.; Kuraishi,C.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, # 12 p. 1137 - 1141
反应条件
1: 54 percent / potassium hydroxide / ethanol / 119 h
2: 76 percent / H2O2; NaOH / methanol; H2O / 24 h / 0 °C
View Scheme
参考文献
Bennett, Christopher J.; Caldwell, Stuart T.; McPhail, Donald B.; Morrice, Philip C.; Duthie, Garry G.; Hartley, Richard C.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 9 p. 2079 - 2098
反应条件
1: K2CO3
2: Cl2, aq. KOH
View Scheme
参考文献
Kobayashi,S.; Kuraishi,C.
Chemical and Pharmaceutical Bulletin, 1962 , vol. 10, # 12 p. 1137 - 1141
