4-氨基-2-(甲基硫代)噻唑-5-羧酰胺合成路线 （共 5 条）
反应条件
sulfuric acid
T=20°C; 1 h;
参考文献
AMBIT BIOSCIENCES CORPORATION; CHAO, Qi; HADD, Michael, J.; HOLLADAY, Mark, W.; ROWBOTTOM, Martin
Patent: WO2012/30924 A1, 2012 ;
Location in patent: Page/Page column 156 ;
WO 2012/030924 A1
反应条件
1: in ethanol
1 h; Reflux;
2: With sodium methylate in ethanol
3 h; Reflux;
参考文献
GLAXOSMITHKLINE LLC; LIN, Hong; LUENGO, Juan, I.; RIVERO, Ralph, A.; SCHULZ, Mark, James; XIE, Ren; ZENG, Jin
Patent: WO2010/135504 A1, 2010 ;
Location in patent: Page/Page column 49 ;
WO 2010/135504 A1
反应条件
1: cyanimidodithiocarbonic acid monomethyl ester monopotassium salt; 2-chloro-acetamide in ethanol
1.5 h; Heating / reflux;
2: sodium methylate in ethanol
T=20°C; 3 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/117890 A2, 2005 ;
Location in patent: Page/Page column 86 ;
WO 2005/117890 A2
反应条件
sodium ethanolate in ethanol
Heating;
参考文献
Wobig,D.
Justus Liebigs Annalen der Chemie, 1977 , p. 400 - 406
反应条件
(i) aq. acetone, (ii) NaOEt, (iii) /BRN= 969135/; Multistep reaction;
参考文献
Wobig,D.
Justus Liebigs Annalen der Chemie, 1977 , p. 400 - 406
