3-溴-5-氯甲基吡啶盐酸盐合成路线 （共 12 条）
反应条件
1: potassium carbonate / acetonitrile / 4 h / 80 °C
2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / acetonitrile / 0.25 h / 160 °C / Sealed tube; Microwave irradiation
View Scheme
参考文献
GLAXO GROUP LIMITED; ALDER, Catherine Mary; BALDWIN, Ian Robert; BARTON, Nicholas Paul; CAMPBELL, Amanda Jennifer; CHAMPIGNY, Aurelie Cecile; HARLING, John David; MAXWELL, Aoife Caitriona; SIMPSON, Juliet Kay; SMITH, Ian Edward David; TAME, Christopher John; WILSON, Caroline; WOOLVEN, James Michael
Patent: WO2011/110575 A1, 2011 ;
WO 2011/110575 A1
反应条件
in ethanol
Substitution; 17 h; Heating;
参考文献
Nutaitis, Charles F.; Ledeboer, Mark W.
Organic Preparations and Procedures International, 1992 , vol. 24, # 2 p. 143 - 146
