1-溴-2,4,6-三叔丁基苯合成路线 （共 38 条）
反应条件
n-butyllithium
anschliessend Behandeln mit CO2;
参考文献
Betts; Barclay
Canadian Journal of Chemistry, 1955 , vol. 33, p. 1768,1769
反应条件
1: 1) butyl-lithium, 2) PCl3 / 1) THF, -78 deg C, 10 min; reflux, 1h
2: 78 percent / sulphuryl chloride / CH2Cl2 / 0.25 h / Ambient temperature
View Scheme
参考文献
Freeman, Sally; Harger, Martin J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1399 - 1406
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere
1.2: -78 - 20 °C
2.1: cerium(III) chloride; lithium aluminium tetrahydride / 1,4-dioxane / 6 h / 101 °C / |Inert atmosphere
View Scheme
参考文献
Fleming, Conor G. E.; Slawin, Alexandra M. Z.; Athukorala Arachchige, Kasun S.; Randall, Rebecca; Buehl, Michael; Kilian, Petr
Dalton Transactions, 2013 , vol. 42, # 5 p. 1437 - 1450
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere
1.2: -78 - 20 °C
2.1: chloro-trimethyl-silane; lithium aluminium tetrahydride / 1,4-dioxane / 5 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
Fleming, Conor G. E.; Slawin, Alexandra M. Z.; Athukorala Arachchige, Kasun S.; Randall, Rebecca; Buehl, Michael; Kilian, Petr
Dalton Transactions, 2013 , vol. 42, # 5 p. 1437 - 1450
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere
1.2: -78 - 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / |Cooling with ice; |Reflux; |Inert atmosphere
View Scheme
参考文献
Fleming, Conor G. E.; Slawin, Alexandra M. Z.; Athukorala Arachchige, Kasun S.; Randall, Rebecca; Buehl, Michael; Kilian, Petr
Dalton Transactions, 2013 , vol. 42, # 5 p. 1437 - 1450
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C, 2 h, 2.) -78 deg C to r.t.
2: LiAlH4 / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Brauer, David J.; Bitterer, Frank; Doerrenbach, Frank; Hessler, Gisbert; Stelzer, Othmar; Krueger, Carl; Lutz, Frank
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 1996 , vol. 51, # 8 p. 1183 - 1196
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane from -78 deg C to RT
2: 23 percent / diethyl ether / Ambient temperature
View Scheme
参考文献
Ishii, Akihiko; Ishida, Takashi; Kumon, Naoko; Fukuda, Nobuo; Oyama, Hiroyuki; Inamoto, Naoki; Iwasaki, Fujiko; Okazaki, Renji
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 3 p. 709 - 717
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane from -78 deg C to RT
2: 39 percent / diethyl ether / Ambient temperature
View Scheme
参考文献
Ishii, Akihiko; Ishida, Takashi; Kumon, Naoko; Fukuda, Nobuo; Oyama, Hiroyuki; Inamoto, Naoki; Iwasaki, Fujiko; Okazaki, Renji
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 3 p. 709 - 717
