4-(4-三氟甲基苯基)-哌啶-4-醇合成路线 （共 3 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol
T=30°C; P=760.051 Torr; 2 h;
参考文献
sanofi-aventis
Patent: US2005/176722 A1, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
potassium hydroxide; water in ethanol
T=20°C; 90 h; Heating / reflux;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/118587 A1, 2005 ;
Location in patent: Page/Page column 214 ;
WO 2005/118587 A1
反应条件
hydrogenchloride in ethyl acetate
T=20°C;
参考文献
Chen, Gang; Xia, Hongguang; Cai, Yu; Ma, Dawei; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 234 - 239
