1,3-二甲基-2-苯基苯合成路线 （共 66 条）
反应条件
N,N,N′,N′-tetra(diphenylphosphinomethyl)-1,2-ethylenediamine; potassium hydroxide; palladium dichloride in 1,4-dioxane; N,N-dimethyl-formamide
T=100°C; Suzuki coupling; 20 h; Inert atmosphere;
参考文献
Wang, Kun; Yi, Tao; Yu, Xiaojun; Zheng, Xueli; Fu, Haiyan; Chen, Hua; Li, Ruixiang
Applied Organometallic Chemistry, 2012 , vol. 26, # 7 p. 342 - 346
反应条件
1: diallyl(diphenyl)silane With tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 1 h;
2: 2-Chloro-1,3-dimethylbenzene With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran; water
T=80°C; 20 h;
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
potassium fluoride; palladium diacetate in tetrahydrofuran
参考文献
Buchwald, Stephen L.; Huang, Xiaohua; Zim, Danilo
Patent: US2004/171833 A1, 2004 ;
反应条件
Pd((CH3)2C6H3NC(CH3)CHC(CH3)NC6H3(CH3)2)(CH3)(P(CH2CH3)3); tetrabutylammomium bromide; sodium hydroxide in water
T=80°C; Hiyama coupling; 12 h; Inert atmosphere;
参考文献
Lee, Dong-Hwan; Jung, Ji-Young; Jin, Myung-Jong
Chemical Communications, 2010 , vol. 46, # 47 p. 9046 - 9048
反应条件
palladium diacetate; caesium carbonate; triphenylphosphine in o-xylene
6 h; Heating;
参考文献
Terao; Wakui; Satoh; Miura; Nomura
Journal of the American Chemical Society, 2001 , vol. 123, # 42 p. 10407 - 10408
反应条件
tetrabutyl ammonium fluoride; bis(dibenzylideneacetone)-palladium(0); 2-dicyclohexylphosphino-1,1'-biphenyl in tetrahydrofuran
T=120°C; 0.166667 h; microwave irradiation;
参考文献
Seganish, W. Michael; DeShong, Philip
Organic Letters, 2004 , vol. 6, # 23 p. 4379 - 4381
反应条件
cesium fluoride in water; N,N-dimethyl-formamide
T=40°C; Stille coupling; 12 h;
参考文献
Wu, Lei; Li, Zhi-Wei; Zhang, Feng; He, Yan-Mei; Fan, Qing-Hua
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 6 p. 846 - 862
反应条件
1: 2,6-dimethylbenzeneamine With hydrogenchloride; sodium nitrite in water
T=0 - 5°C;
2: With sodium tetrafluoroborate in water
0.166667 h;
3: monophenyl triethoxy silane With tetrabutyl ammonium fluoride; palladium diacetate in water
T=25°C; Hiyama Coupling; 6 h;
参考文献
Cheng, Kai; Zhao, Baoli; Hu, Sai; Zhang, Xian-Man; Qi, Chenze
Tetrahedron Letters, 2013 , vol. 54, # 46 p. 6211 - 6214
反应条件
1: 2,6-dimethylbenzeneamine With hydrogenchloride; sodium nitrite in water
T=25°C;
2: With sodium tetrafluoroborate in water
0.166667 h;
3: PhBF3(-)K(+) With palladium diacetate; sodium carbonate in water
T=25°C; Suzuki-Miyaura Coupling; 6 h;
参考文献
Cheng, Kai; Zhao, Baoli; Hu, Sai; Zhang, Xian-Man; Qi, Chenze
Tetrahedron Letters, 2013 , vol. 54, # 46 p. 6211 - 6214
反应条件
tetrabutyl ammonium fluoride; tris-(o-tolyl)phosphine; dichloro bis(acetonitrile) palladium(II)
T=80°C; Hiyama cross-coupling reaction; 0.75 h;
参考文献
Li, Jin-Heng; Deng, Chen-Liang; Xie, Ye-Xiang
Synthesis, 2006 , # 6 p. 969 - 974
