(R)-3-羟基丁酸甲酯合成路线 （共 39 条）
反应条件
lt;Ru((R)-(+)-BINAPgt; cat; hydrogen in methanol; dichloromethane T=25°C; P=77572.2 Torr; 48 h;
参考文献
Pye, Philip J.; Rossen, Kai; Reamer, Robert A.; Volante; Reider, Paul J.
Tetrahedron Letters, 1998 , vol. 39, # 25 p. 4441 - 4444
反应条件
sulfuric acid in 1,2-dichloro-ethane T=80°C; 120 h; Heating / reflux;
参考文献
KETOCYTONYX INC.
Patent: WO2006/12490 A2, 2006 ;
Location in patent: Page/Page column 8 ;
反应条件
Ru2Cl4-(S)-(2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2*NEt3; hydrogen in methanol T=35°C; P=76000.1 Torr; 48 h; Title compound not separated from byproducts;
参考文献
Shao, Liming; Takeuchi, Kasumi; Ikemoto, Makoto; Kawai, Toshiyasu; Ogasawara, Masamichi; et al.
Journal of Organometallic Chemistry, 1992 , vol. 435, # 1.2 p. 133 - 147
反应条件
[Ru(η4-COD)(η3-methylallyl)2]; hydrogen in methanol T=60°C; P=30003 Torr; 20 h; Reagent/catalystSolvent; Optical yield = 89 percent ee; enantioselective reaction;
参考文献
Jin, Xin; Kong, Fang-Fang; Yang, Zhi-Qiang; Cui, Fei-Fei
Journal of Molecular Catalysis A: Chemical, 2013 , vol. 374-375, p. 22 - 26
反应条件
3-hydroxy-pyridine; dicobalt octacarbonyl in tetrahydrofuran T=65°C; P=31028.9 Torr; 9 h;
参考文献
Hinterding, Klaus; Jacobsen, Eric N.
Journal of Organic Chemistry, 1999 , vol. 64, # 7 p. 2164 - 2165
参考文献
Nicolaou, K. C.; Pavia, M. R.; Seitz, S. P.
Journal of the American Chemical Society, 1981 , vol. 103, # 5 p. 1224 - 1226
反应条件
sodium peroxoborate tetrahydrate in tetrahydrofuran; water T=20°C; 1 h;
参考文献
Reis, Joel S.; Andrade, Leandro H.
Tetrahedron Asymmetry, 2012 , vol. 23, # 17 p. 1294 - 1300
反应条件
hydrogenchloride; hydrogen; [RuCl2-((R)-binap)]*NEt3 in methanol T=40°C; P=2585.7 Torr; 8 h; effect of acid, other substrate; Kinetics;
参考文献
King, Steven A.; Thompson, Andrew S.; King, Anthony O.; Verhoeven, Thomas R.
Journal of Organic Chemistry, 1992 , vol. 57, # 25 p. 6689 - 6691
反应条件
hydrogen; [Ru(p-cymene)I-(S)-binap]I in methanol T=30°C; P=76000 Torr; 35 h; other: catalysts, solvents, time, pressure, temperatures; Product distribution;
参考文献
Mashima, Kazushi; Kusano, Koh-hei; Sato, Naomasa; Matsumura, Yoh-ichi; Nozaki, Kyoko; et al.
Journal of Organic Chemistry, 1994 , vol. 59, # 11 p. 3064 - 3076
反应条件
scandium tris(trifluoromethanesulfonate) T=64°C; 10 h;
参考文献
Remme, Nicole; Koschek, Katharina; Schneider, Christoph
Synlett, 2007 , # 3 p. 491 - 493
