(R)-3-羟基丁酸甲酯合成路线 （共 39 条）
反应条件
N,N-bis-2-(hydroxyethyl)-2-amino ethane sulfonic acid; lipase from Ophiostoma piliferum in water T=25°C; pH=7.20; Enzyme kinetics;
参考文献
Liu, Andrew Man Fai; Somers, Neil A.; Kazlauskas, Romas J.; Brush, Terry S.; Zocher, Frank; Enzelberger, Markus M.; Bornscheuer, Uwe T.; Horsman, Geoff P.; Mezzetti, Alessandra; Schmidt-Dannert, Claudia; Schmid, Rolf D.
Tetrahedron Asymmetry, 2001 , vol. 12, # 4 p. 545 - 556
反应条件
boron trifluoride diethyl etherate in diethyl ether 24 h; Ambient temperature;
参考文献
Lin; Lee; Klayman
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1249 - 1252
反应条件
1: 98 percent / pyridine / 24 h / 0 °C 2: formamide; tetrahydrofuran / 72 h / 25 °C / displacement of other benzenesulfonate groups; other solvents View Scheme
参考文献
Blacklock; Sohar; Butcher; Lamanec; Grabowski
Journal of Organic Chemistry, 1993 , vol. 58, # 7 p. 1672 - 1679
反应条件
hydrogen; C52H53BN2P2Ru in tetrahydrofuran T=80°C; P=37503.8 Torr; 16 h; Product distribution / selectivity;
参考文献
TAKASAGO INTERNATIONAL CORPORATION
Patent: US2010/63294 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
RuH(η1-BH4)(dppp)((R,R)-dpen); hydrogen in tetrahydrofuran T=80°C; P=37503.8 Torr; 16 h; Autoclave;
参考文献
Kuriyama, Wataru; Ino, Yasunori; Ogata, Osamu; Sayo, Noboru; Saito, Takao
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 1 p. 92 - 96
反应条件
1: 76 percent / pyridine / CH2Cl2 / 2 h / 40 °C 2: 32 percent / CF3SO3H / 10 h / 80 °C View Scheme
参考文献
Effenberger, Franz; Weber, Thomas
Chemische Berichte, 1988 , vol. 121, p. 421 - 430
反应条件
n-butyllithium; diisopropylamine 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, DMPU, 15 min and 0 deg C, 45 min; Yield given. Multistep reaction;
参考文献
Kraft; Tochtermann
Tetrahedron, 1995 , vol. 51, # 40 p. 10875 - 10882
反应条件
RuH(η1-BH4)(dppp)((R,R)-dpen); hydrogen in tetrahydrofuran T=80°C; P=37503.8 Torr; 16 h; Autoclave;
参考文献
Kuriyama, Wataru; Ino, Yasunori; Ogata, Osamu; Sayo, Noboru; Saito, Takao
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 1 p. 92 - 96
反应条件
trifluorormethanesulfonic acid in dichloromethane; cyclohexane
Ambient temperature;
参考文献
Seebach, Dieter; Braendli, Urs; Schnurrenberger, Peter; Przybylski, Michael
Helvetica Chimica Acta, 1988 , vol. 71, p. 155 - 167
