2-氨基-4-羟基-6-甲基嘧啶合成路线 （共 33 条）
反应条件
1: 83 percent / fuming HNO3, conc. H2SO4 / 0.75 h / Ambient temperature 2: 27 percent / POCl3 / 3 h / Heating 3: 68 percent / NH3 / ethanol / 4 h / 100 °C View Scheme
参考文献
Bowden, Keith; Bright, Andrew C.
Journal of Chemical Research, Miniprint, 1992 , # 2 p. 514 - 539
反应条件
1: With iodine in sodium hydroxide T=80°C; 2: With trichlorophosphate
参考文献
Pal, Manojit; Batchu, Venkateswara Rao; Swamy, Nalivela Kumara; Padakanti, Srinivas
Tetrahedron Letters, 2006 , vol. 47, # 23 p. 3923 - 3928
反应条件
in N,N-dimethyl-formamide 3 h; Heating;
参考文献
Laneri; Sacchi; Abignente
Journal of Heterocyclic Chemistry, 2000 , vol. 37, # 5 p. 1265 - 1267
反应条件
phosphorus oxytribromide
参考文献
Golding; Senear
Journal of Organic Chemistry, 1947 , vol. 12, p. 293
反应条件
1: 89 percent / conc. HNO3, conc. H2SO4 / 3 h / Ambient temperature 2: 91 percent / CH2Cl2 / 5 h / Ambient temperature 3: 60 percent / NaH / dimethylformamide / 1.) r.t., 1 h, 2.) r.t., 12 h 4: 86 percent / dimethylformamide / 12 h / Ambient temperature 5: 94 percent / aq. Na2S2O4 / tetrahydrofuran / 1 h / Ambient temperature 6: 48 percent / 1 N NaOH / tetrahydrofuran / 96 h / Ambient temperature View Scheme
参考文献
Taylor, Edward C.; Young, Wendy B.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7947 - 7952
反应条件
bromine; acetic acid
参考文献
Wierenga; Skulnick; Stringfellow; Weed; Renis; Eidson
Journal of Medicinal Chemistry, 1980 , vol. 23, # 3 p. 237 - 239
反应条件
1: phosphorus oxychloride / Heating 2: zinc dust; aq. ammonium chloride / Heating View Scheme
参考文献
Becker, Irwin
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 3 p. 343 - 348
反应条件
1: With bromine in acetic acid 2: With trichlorophosphate
参考文献
Hull et al.
Journal of the Chemical Society, 1947 , p. 41,45
Full Text Show Details
Price et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 766,768
反应条件
1: 80 percent / nitric acid / H2SO4 / 1 h / 50 °C 2: 92 percent / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Taylor, Edward C.; Young, Wendy B.
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 7947 - 7952
反应条件
N-iodo-succinimide in water; acetic acid
参考文献
The Upjohn Company
Patent: US3932617 A1, 1976 ;
