O-(3-丁烯基)-N,N-二(2-氯乙基)磷二酰胺合成路线 （共 7 条）
反应条件
ammonia in tetrahydrofuran 2 h; Ambient temperature; Yield given;
参考文献
Borch, Richard F.; Valente, Ronald R.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 3052 - 3058
反应条件
(i) POCl3, CH2Cl2, (ii) /BRN= 3550356/, Et3N, (iii) NH3; Multistep reaction;
参考文献
Borch; Hoye; Swanson
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 490 - 494
反应条件
n-butyllithium; ammonia Yield given. Multistep reaction;
参考文献
Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485
反应条件
1: 27 percent / ozone, 30percent aq. H2O2 / acetone; H2O / Ambient temperature 2: Ph3P / CH2Cl2 / 0.25 h / Ambient temperature View Scheme
参考文献
Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485
反应条件
1: 27 percent / ozone, 30percent aq. H2O2 / acetone; H2O / Ambient temperature 2: Ph3P / CH2Cl2 / 0.25 h / Ambient temperature View Scheme
参考文献
Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485
反应条件
1: 27 percent / ozone, 30percent aq. H2O2 / acetone; H2O / Ambient temperature
2: 1.) Ph3P, 2.) trichloroacetic acid / 1.) CH2Cl2, RT, 15 min, 2.) CH2Cl2, 5 deg C, 1 h
View Scheme
参考文献
Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485
反应条件
dihydrogen peroxide; ozone in water; acetone
Ambient temperature;
参考文献
Zon, Gerald; Ludeman, Susan Marie; Brandt, Joan A.; Boyd, Victoria L.; Oezkan, Gunay; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 466 - 485
