9-[4-羟基-3-(羟甲基)-丁基]-鸟嘌呤合成路线 （共 58 条）
反应条件
1.1: 47 percent / HCl / H2O; dioxane / 18 h / 20 °C 2.1: 95 percent / NEt3; DMAP; 3 Angstroem molecular sieves / acetonitrile / 1 h / 20 °C 3.1: bis(trimethylsilyl)acetamide / 1-methyl-pyrrolidin-2-one / 80 °C 3.2: 70 percent / TMSOTf / 1-methyl-pyrrolidin-2-one / 24 h / 0 °C 4.1: 87 percent / aq. NaOH / 3 h / 20 °C 5.1: 10 percent / DIBAL-H / tetrahydrofuran / 48 h / 20 °C View Scheme
参考文献
Geen, Graham R.; Kincey, Peter M.; Spoors, P. Grant
Tetrahedron Letters, 2001 , vol. 42, # 9 p. 1781 - 1784
反应条件
1.1: bis(trimethylsilyl)acetamide / 1-methyl-pyrrolidin-2-one / 80 °C 1.2: 70 percent / TMSOTf / 1-methyl-pyrrolidin-2-one / 24 h / 0 °C 2.1: 87 percent / aq. NaOH / 3 h / 20 °C 3.1: 10 percent / DIBAL-H / tetrahydrofuran / 48 h / 20 °C View Scheme
参考文献
Geen, Graham R.; Kincey, Peter M.; Spoors, P. Grant
Tetrahedron Letters, 2001 , vol. 42, # 9 p. 1781 - 1784
反应条件
1: 87 percent / aq. NaOH / 3 h / 20 °C 2: 10 percent / DIBAL-H / tetrahydrofuran / 48 h / 20 °C View Scheme
参考文献
Geen, Graham R.; Kincey, Peter M.; Spoors, P. Grant
Tetrahedron Letters, 2001 , vol. 42, # 9 p. 1781 - 1784
反应条件
1: Et3N / CH2Cl2 / 2 h / -5 °C 2: potassium carbonate / dimethylformamide / 18 h / 40 °C 3: 98 percent / aq. HCl / 3 h / Heating View Scheme
参考文献
Brand, Briony; Reese, Colin B.; Song, Quanlai; Visintin, Cristina
Tetrahedron, 1999 , vol. 55, # 16 p. 5239 - 5252
反应条件
1: potassium carbonate / dimethylformamide / 18 h / 40 °C 2: 98 percent / aq. HCl / 3 h / Heating View Scheme
参考文献
Brand, Briony; Reese, Colin B.; Song, Quanlai; Visintin, Cristina
Tetrahedron, 1999 , vol. 55, # 16 p. 5239 - 5252
反应条件
1: 94 percent / acetic acid; H2O / 20 h / 30 °C 2: Et3N / CH2Cl2 / 2 h / -5 °C 3: potassium carbonate / dimethylformamide / 18 h / 40 °C 4: 98 percent / aq. HCl / 3 h / Heating View Scheme
参考文献
Brand, Briony; Reese, Colin B.; Song, Quanlai; Visintin, Cristina
Tetrahedron, 1999 , vol. 55, # 16 p. 5239 - 5252
反应条件
1: NaBH4 / 2-methyl-propan-2-ol; methanol / 3 h / Heating 2: pyridine / 20 h / Ambient temperature 3: 94 percent / acetic acid; H2O / 20 h / 30 °C 4: Et3N / CH2Cl2 / 2 h / -5 °C 5: potassium carbonate / dimethylformamide / 18 h / 40 °C 6: 98 percent / aq. HCl / 3 h / Heating View Scheme
参考文献
Brand, Briony; Reese, Colin B.; Song, Quanlai; Visintin, Cristina
Tetrahedron, 1999 , vol. 55, # 16 p. 5239 - 5252
反应条件
hydrogenchloride in ethanol 6 h; Heating;
参考文献
Hannah; Tolman; Karkas; Liou; Perry; Field
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1261 - 1271
反应条件
hydrogenchloride in methanol 0.166667 h;
参考文献
Hannah; Tolman; Karkas; Liou; Perry; Field
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1261 - 1271
反应条件
hydrogenchloride Heating;
参考文献
Choudary; Geen; Grinter; MacBeath; Parratt
Nucleosides and Nucleotides, 1994 , vol. 13, # 4 p. 979 - 996
