9-[4-羟基-3-(羟甲基)-丁基]-鸟嘌呤合成路线 （共 58 条）
反应条件
1: 530 mg / sodium hydride / dimethylformamide / 22 °C 2: 156 mg / aq. N hydrochloric acid / methanol / 0.17 h View Scheme
参考文献
Hannah; Tolman; Karkas; Liou; Perry; Field
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 5 p. 1261 - 1271
反应条件
1: 95 percent / thionyl chloride / 40 - 45 °C 2: 78 percent / sodium borohydride / propan-2-ol; H2O / 2.5 h / 40 °C View Scheme
参考文献
Torii, Takayoshi; Yamashita, Keizo; Kojima, Mitsuhiko; Suzuki, Yumiko; Hijiya, Toyoto; Izawa, Kunisuke
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 4-6 p. 625 - 634
反应条件
1: 65 percent / Et3N, DMAP / CH2Cl2 / 2 h / Heating 2: 94 percent / aq. HCl / 3 h / Heating View Scheme
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
反应条件
1: 87 percent / HCl / 16 h / Ambient temperature 2: 57 percent / NaBH4, MeOH / 2-methyl-propan-2-ol / 1.75 h / Heating 3: 76 percent / aq. NaOH / 3 h / 90 °C View Scheme
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
反应条件
1: NaBH4 / CH2Cl2; methanol / 3.5 h / 20 - 22 °C 2: 65 percent / Et3N, DMAP / CH2Cl2 / 2 h / Heating 3: 94 percent / aq. HCl / 3 h / Heating View Scheme
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
反应条件
1: 57 percent / NaBH4, MeOH / 2-methyl-propan-2-ol / 1.75 h / Heating 2: 76 percent / aq. NaOH / 3 h / 90 °C View Scheme
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
反应条件
1: Et3N / CH2Cl2 / 1 h / -5 °C 2: sodium iodide / acetone / 2 h / Heating 3: 74 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature 4: 50 percent / aq. hydrochloric acid / Heating View Scheme
参考文献
Choudary; Geen; Grinter; MacBeath; Parratt
Nucleosides and Nucleotides, 1994 , vol. 13, # 4 p. 979 - 996
反应条件
1: sodium iodide / acetone / 2 h / Heating 2: 74 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature 3: 50 percent / aq. hydrochloric acid / Heating View Scheme
参考文献
Choudary; Geen; Grinter; MacBeath; Parratt
Nucleosides and Nucleotides, 1994 , vol. 13, # 4 p. 979 - 996
反应条件
1: 70 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature 2: 67 percent / aq. hydrochloric acid / 2.5 h / Heating View Scheme
参考文献
Choudary; Geen; Grinter; MacBeath; Parratt
Nucleosides and Nucleotides, 1994 , vol. 13, # 4 p. 979 - 996
反应条件
1: 74 percent / K2CO3 / dimethylformamide / 18 h / Ambient temperature 2: 50 percent / aq. hydrochloric acid / Heating View Scheme
参考文献
Choudary; Geen; Grinter; MacBeath; Parratt
Nucleosides and Nucleotides, 1994 , vol. 13, # 4 p. 979 - 996
