9-[4-羟基-3-(羟甲基)-丁基]-鸟嘌呤合成路线 （共 58 条）
反应条件
sodium hydroxide 0.5 h; Heating;
参考文献
Kalayanov, Genadiy; Jaksa, Suzana; Scarcia, Tommaso; Kobe, Joze
Synthesis, 2004 , # 12 p. 2026 - 2034
反应条件
1: 54.4 percent / DMAP; Et3N / dimethylformamide / 20 °C 2: 70.5 percent / pyridine; CH2Cl2 / 0 °C View Scheme
参考文献
Wang, Ji-Quan; Zheng, Qi-Huang; Fei, Xiangshu; Mock, Bruce H.; Hutchins, Gary D.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3933 - 3938
反应条件
1: 9-(4-hydroxy-3-hydroxymethylbut-1-yl)-guanine; diphenyl-(4-methoxyphenyl)-methyl chloride 2: p-toluenesulfonyl chloride With pyridine
参考文献
Board of Regents, The University of Texas System; Cell>Point LLC
Patent: US2005/129619 A1, 2005 ;
Location in patent: Sheet 20 ;
反应条件
1: 91 percent / 4-(dimethylamino)pyridine / dimethylformamide / 1.5 h / 45 °C 2: 70 percent / tetraethylammonium chloride; N,N-dimethylaniline; phosphorus oxychloride / acetonitrile / 1 h / 70 °C View Scheme
参考文献
Torii, Takayoshi; Shiragami, Hiroshi; Yamashita, Keizo; Suzuki, Yumiko; Hijiya, Toyoto; Kashiwagi, Tatsuki; Izawa, Kunisuke
Tetrahedron, 2006 , vol. 62, # 24 p. 5709 - 5716
反应条件
1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 2: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 3: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 4: 99 percent / aq. MeNH2 / 0.25 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
反应条件
1: 83 percent / 1-methyl-pyrrolidin-2-one / 5 h / 150 °C 2: 99 percent / Et3N; DMAP / CH2Cl2 / 2.5 h / 20 °C 3: 60 percent / H2; Et3N / Pd/C / ethanol / 8 h / 80 - 85 °C / 2250.18 Torr 4: 99 percent / aq. MeNH2 / 0.25 h / 20 °C 5: 97 percent / pyridine; DMAP / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Synthesis, , # 12 p. 2026 - 2034
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide
64 h; Ambient temperature;
参考文献
Harnden, Michael R.; Jarvest, Richard L.; Bacon, Teresa H.; Boyd, Malcolm R.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1636 - 1642
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide
0.666667 h; Ambient temperature;
参考文献
Harnden, Michael R.; Jarvest, Richard L.; Bacon, Teresa H.; Boyd, Malcolm R.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1636 - 1642
