1-(四氢-2H-吡喃-4-基)哌嗪合成路线 (共 4 条)
反应条件
hydrogen; palladium on activated charcoal in methanol 6 h;
参考文献
AMOREPACIFIC CORPORATION; CRYSTALGENOMICS, INC.; INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY of Yonsei University
Patent: WO2008/72850 A1, 2008 ;
Location in patent: Page/Page column 38 ;
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 1 h;
参考文献
Zaragoza, Florencio; Stephensen, Henrik; Knudsen, Sanne M.; Pridal, Lone; Wulff, Birgitte S.; Rimvall, Karin
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2833 - 2838
反应条件
1: NaCNBH3; aq. AcOH / tetrahydrofuran / 60 °C 2: TFA / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Zaragoza, Florencio; Stephensen, Henrik; Knudsen, Sanne M.; Pridal, Lone; Wulff, Birgitte S.; Rimvall, Karin
Journal of Medicinal Chemistry, 2004 , vol. 47, # 11 p. 2833 - 2838
参考文献
Ushio, Hiroyuki; Naito, Youichiro; Sugiyama, Naoki; Kawaguchi, Takafumi; Ohtsuki, Makio; Chiba, Kenji
Patent: US2003/203909 A1, 2003 ;