6-氯-9-beta-D-(2,3-异亚丙基)呋喃核糖基嘌呤合成路线 （共 7 条）
反应条件
in perchloric acid 3 h; Ambient temperature;
参考文献
Zhu, Zhengxiang; Buolamwini, John K.
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 3848 - 3865
反应条件
1: With toluene-4-sulfonic acid in acetone T=20°C; 16 h; 2: With water; sodium hydrogencarbonate in acetone
参考文献
MILLENNIUM PHARMACEUTICALS, INC.
Patent: WO2006/84281 A1, 2006 ;
Location in patent: Page/Page column 78-79 ;
反应条件
1: 90 percent / chloromethylenedimethyliminium chloride / CHCl3 / 3 h / Heating 2: methanolic NH3 / 16 h / 4 °C 3: p-TsOH, acetone / 0.75 h / 24 °C View Scheme
参考文献
Camp, David; Li, Ying; McCluskey, Adam; Moni, Roger W.; Quinn, Ronald J.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 6 p. 695 - 698
参考文献
Qu, Gui-Rong; Xia, Ran; Yang, Xi-Ning; Li, Jian-Guo; Wang, Dong-Chao; Guo, Hai-Ming
Journal of Organic Chemistry, 2008 , vol. 73, # 6 p. 2416 - 2419
反应条件
1: methanolic NH3 / 16 h / 4 °C 2: p-TsOH, acetone / 0.75 h / 24 °C View Scheme
参考文献
Camp, David; Li, Ying; McCluskey, Adam; Moni, Roger W.; Quinn, Ronald J.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 6 p. 695 - 698
反应条件
1: 21 percent / dimethylformamide / 24 h / 50 - 55 °C
2: 36 percent / CF3COOH / 2 h / Ambient temperature
View Scheme
参考文献
Zemlicka, Jiri; Endo, Takeshi
Nucleosides and Nucleotides, 1996 , vol. 15, # 1-3 p. 619 - 629
反应条件
ueber mehrere Stufen;
参考文献
Hampton; Maguire
Journal of the American Chemical Society, 1961 , vol. 83, p. 150,154
Full Text Show Details
Hampton et al.
Pr.4.int.Congr.Biochem.Wien 1958,Bd.15,S.40
