1-苯并噻吩-3-羰酰氯合成路线 （共 10 条）
反应条件
thionyl chloride 4 h; Heating;
参考文献
Shafiee; Hedayati; Salimi; Faghihi
Journal of Pharmaceutical Sciences, 1983 , vol. 72, # 2 p. 198 - 202
反应条件
1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / acetone 2: (COCl)2; DMF / toluene / 3 h / 20 °C View Scheme
参考文献
Tietze, Lutz F.; Lohmann, J. Klaas
Synlett, 2002 , # 12 p. 2083 - 2085
反应条件
1.1: nBuLi / diethyl ether / -78 °C 1.2: diethyl ether / -78 °C 2.1: aq. NaClO2; NaH2PO4; 2-methyl-2-butene / acetone 3.1: (COCl)2; DMF / toluene / 3 h / 20 °C View Scheme
参考文献
Tietze, Lutz F.; Lohmann, J. Klaas
Synlett, 2002 , # 12 p. 2083 - 2085
参考文献
Shirley et al.
Journal of Organic Chemistry, 1958 , vol. 23, p. 1024
反应条件
1: diethyl ether 2: ethanol; silver oxide / Erwaermen der Reaktionsloesung mit wss. Kalilauge View Scheme
参考文献
Crook; Davies
Journal of the Chemical Society, 1937 , p. 1697
反应条件
sodium azide in water; acetone
0.25 h;
参考文献
Galvez, Carmen; Garcia, Francisco; Veiga, Montserrat; Viladoms, Pere
Synthesis, 1983 , # 11 p. 932 - 933
反应条件
1: 96 percent / NaN3 / acetone; H2O / 0.25 h
2: 85 percent / 2 h / Heating
View Scheme
参考文献
Galvez, Carmen; Garcia, Francisco; Veiga, Montserrat; Viladoms, Pere
Synthesis, 1983 , # 11 p. 932 - 933
反应条件
1: 96 percent / NaN3 / acetone; H2O / 0.25 h
2: 85 percent / 2 h / Heating
3: 71 percent / Br2 / methanol / 0.08 h
View Scheme
参考文献
Galvez, Carmen; Garcia, Francisco; Veiga, Montserrat; Viladoms, Pere
Synthesis, 1983 , # 11 p. 932 - 933
参考文献
Neckers, Douglas C.; Wagenaar, Frank L.
Tetrahedron Letters, 1984 , vol. 25, # 28 p. 2931 - 2934
反应条件
1: 96 percent / NaN3 / acetone; H2O / 0.25 h
2: 85 percent / 2 h / Heating
3: 69 percent / K2CO3, Cl2 / CCl4 / 0.25 h / 0 °C
4: 90 percent / HBr / CH2Cl2
5: 83 percent / Na2CO3 / H2O
View Scheme
参考文献
Galvez, Carmen; Garcia, Francisco; Veiga, Montserrat; Viladoms, Pere
Synthesis, 1983 , # 11 p. 932 - 933
