2-羟基-5-硝基苯甲腈合成路线 （共 26 条）
反应条件
sodium azide; chloroform; sulfuric acid
参考文献
Palazzo; Tornetta
Annali di Chimica (Rome, Italy), 1958 , vol. 48, p. 657,660
反应条件
potassium carbonate; methyl iodide in water; acetone
反应条件
tert.-butylhydroperoxide; sodium hydroxide; ammonia in tetrahydrofuran
0.25 h;
参考文献
Makosza, Mieczyslaw; Sienkiewicz, Krzysztof
Journal of Organic Chemistry, 1998 , vol. 63, # 13 p. 4199 - 4208
反应条件
sodium hydroxide in ethanol
T=25°C;
参考文献
Zamri; Schalk; Pattus; Abdallah
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 6 p. 1147 - 1150
反应条件
tert.-butylhydroperoxide; sodium hydroxide in ammonia
T=-33°C;
参考文献
Makosza, Mieczyslaw; Sienkiewicz, Krzysztof
Journal of Organic Chemistry, 1998 , vol. 63, # 13 p. 4199 - 4208
反应条件
nitric acid; acetic acid in water
T=45 - 50°C; 1 h;
参考文献
BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2004/39764 A1, 2004 ;
Location in patent: Page/Page column 88 ;
WO 2004/039764 A1
反应条件
antibody 34E4 in phosphate buffer
T=20°C; pH=7.4; Kinetics; Further Variations:ReagentsSolvents;
参考文献
Hu, Yunfeng; Houk; Kikuchi, Kazuya; Hotta, Kinya; Hilvert, Donald
Journal of the American Chemical Society, 2004 , vol. 126, # 26 p. 8197 - 8205
反应条件
phosphate buffer in water
T=20°C; antibody 21D8; also for uncatalysed reaction; Rate constant;
参考文献
Lewis, Cristina; Paneth, Piotr; O'Leary, Marion H.; Hilvert, Donald
Journal of the American Chemical Society, 1993 , vol. 115, # 4 p. 1410 - 1413
反应条件
hydrogenchloride; tri-(hydroxymethyl)-methylamine
T=20°C; 25E10 monoclonal antibody; var. monoclonal antibodies, also in the presence of inhibitor: acetamido-1,5-naphthalenedisulfonate; ΔH(excit.), ΔS(excit.); Rate constantThermodynamic data;
参考文献
Tarasow; Lewis; Hilvert
Journal of the American Chemical Society, 1994 , vol. 116, # 18 p. 7959 - 7963
参考文献
Lindemann; Thiele
Justus Liebigs Annalen der Chemie, 1926 , vol. 449, p. 75
