2-羟基-5-甲氧基苯甲腈合成路线 （共 16 条）
反应条件
Mont KSF; hydroxylamine hydrochloride; silica gel 0.0666667 h; microwave irradiation;
参考文献
Dewan, Sharwan K.; Singh, Ravinder; Kumar, Anil
Synthetic Communications, 2004 , vol. 34, # 11 p. 2025 - 2029
反应条件
1: With 2-F-octylethanethiol; potassium tert-butylate in N,N-dimethyl-formamide T=110°C; 1 h; Inert atmosphere; 2: With hydrogenchloride in water pH=1; Cooling with ice;
参考文献
Loidreau, Yvonnick; Marchand, Pascal; Dubouilh-Benard, Carole; Nourrisson, Marie-Renee; Duflos, Muriel; Loaec, Nadege; Meijer, Laurent; Besson, Thierry
European Journal of Medicinal Chemistry, 2013 , vol. 59, p. 283 - 295
反应条件
1: With 2-(methylsulfonyl)ethyl alcohol; sodium hydride in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 2 h; 2: With hydrogenchloride; water in DMF (N,N-dimethyl-formamide)
参考文献
TIBOTEC PHARMACEUTICALS Ltd.
Patent: WO2005/111044 A1, 2005 ;
Location in patent: Page/Page column 71-73 ;
反应条件
sodium acetate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; acetic acid
参考文献
Hoffmann-La Roche Inc.
Patent: US6617346 B1, 2003 ;
反应条件
trifluoromethylsulfonic anhydride; triethylamine in dichloromethane T=20°C; 12.5 h; Cooling with ice;
参考文献
Novartis AG
Patent: US2010/75966 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=185°C; 24 h;
参考文献
Hwu, Jih Ru; Hsu, Chia Hao; Wong, Fong Fuh; Chung, Chung-Sun; Hakimelahi, Gholam H.
Synthesis, 1998 , # 3 p. 329 - 332
反应条件
triethylamine in acetonitrile T=80°C; 16 h;
参考文献
Kiss, Arpad; Hell, Zoltan
Synthetic Communications, 2013 , vol. 43, # 13 p. 1778 - 1786
反应条件
2-(N,N-diethylamino)ethanethiol hydrochloride; sodium t-butanolate in N,N-dimethyl-formamide 0.25 h; Heating;
参考文献
Magano, Javier; Chen, Michael H.; Clark, Jerry D.; Nussbaumer, Thomas
Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 7103 - 7105
反应条件
Burgess Reagent in tetrahydrofuran Dehydration; 1 h; Heating;
参考文献
Miller; Kaufman
Synlett, 2000 , # 8 p. 1169 - 1171
反应条件
sodium hydroxide; aluminium trichloride; boron trichloride 1.) dichloroethane, room temp., 16 h, 2.) 80 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Adachi, Makoto; Sugasawa, Tsutomu
Synthetic Communications, 1990 , vol. 20, # 1 p. 71 - 84
