3-(4-氯苯甲酰)丙酸合成路线 （共 38 条）
反应条件
potassium hydroxide; hydrazine hydrate in dichloromethane; water; diethylene glycol
参考文献
Larsen, Scott D.; May, Paul D.; Bleasdale, John E.; Liljebris, Charlotta; Schostarez, Heinrich Josef; Barf, Tjeerd; Nilsson, Marianne
Patent: US6410585 B1, 2002 ;
US 6410585 B1
参考文献
Julia,M. et al.
Bulletin de la Societe Chimique de France, 1960 , p. 304 - 312
反应条件
acetyl chloride 0.5 h; Heating;
参考文献
Tsolomitis, A.; Sandris, C.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1545 - 1548
参考文献
Allen; Normington; Wilson
Canadian Journal of Research, 1934 , vol. 11, p. 386
Chem. Zentralbl., 1935 , vol. 106, # I p. 893
反应条件
hydrazine in ethanol
参考文献
Ortho Pharmaceutical Corporation
Patent: US5684151 A1, 1997 ;
反应条件
1: 84 percent / acetic acid / Heating 2: 78 percent / Br2 / acetic acid / 1 h / 80 °C View Scheme
参考文献
Volynets, N. F.; Smartseva, I. V.; Khramova, I. V.; Pavlova, L. A.
Journal of Organic Chemistry USSR (English Translation), 1984 , p. 1604 - 1608
Zhurnal Organicheskoi Khimii, 1984 , vol. 20, # 8 p. 1760 - 1764
反应条件
1: hydrazine hydrate; calcium chloride; potassium hydroxide / diethylene glycol / 4 h / 150 - 170 °C 2: sulfuric acid / 80 °C View Scheme
参考文献
Louvel, Julien; Carvalho, Joao F.S.; Yu, Zhiyi; Soethoudt, Marjolein; Lenselink, Eelke B.; Klaasse, Elisabeth; Brussee, Johannes; Ijzerman, Adriaan P.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9427 - 9440
反应条件
sodium hydroxide; sodium hydrogencarbonate; sodium carbonate; potassium hexacyanoferrate(III); osmium(VIII) oxide in water T=36.85°C; pH=10.33; Kinetics; Further Variations:pH-values;
参考文献
Reddy, Cherkupally Sanjeeva; Manjari, Padma Sunitha
Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, 2010 , vol. 49, # 4 p. 418 - 424
反应条件
potassium hydroxide; hydrazine hydrate in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water; 1,2-bis-(2-hydroxyethoxy)-ethane
参考文献
Imperial Chemical Industries PLC
Patent: US5254683 A1, 1993 ;
反应条件
1.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / 18 h / 0 - 25 °C 2.1: ammonium acetate / methanol / 1 h / 25 °C 2.2: 18 h / |Reflux View Scheme
参考文献
ARES TRADING S.A.; WHITTAKER, Ben; STEELE, Chris; HARDICK, David; MITCHELL, Dale; POMEL, Vincent; QUATTROPANI, Anna; BEHER, Dirk
Patent: WO2014/12614 A1, 2014 ;
