3-(4-氯苯甲酰)丙酸合成路线 （共 38 条）
反应条件
potassium carbonate in acetone
esterification; Heating;
参考文献
Khan; Siddiqui
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 8 p. 614 - 619
反应条件
1: 71 percent / BH3*t-BuNH2; AlCl3 / CH2Cl2 / 216 h / Heating
2: 70 percent / pyridine / 3.5 h / 0 - 20 °C
View Scheme
参考文献
Yu; Kim; Park; Yang; Herdering; Knoechel
Journal of Labelled Compounds and Radiopharmaceuticals, 2003 , vol. 46, # 12 p. 1151 - 1160
反应条件
1: hydrazine hydrate; calcium chloride; potassium hydroxide / diethylene glycol / 4 h / 150 - 170 °C
2: sulfuric acid / 80 °C
3: diisobutylaluminium hydride / water; dichloromethane; toluene / 1 h / -78 - 20 °C
View Scheme
参考文献
Jefferies, Latisha R.; Cook, Silas P.
Organic Letters, 2014 , vol. 16, # 7 p. 2026 - 2029
反应条件
1: chloroform; bromine
2: isopropyl alcohol
View Scheme
参考文献
Knott
Journal of the Chemical Society, 1945 , p. 455,457
反应条件
1: sodium acetate; hydrazine hydrate / methanol / 6 h / Reflux
2: trichlorophosphate / 6 h / Heating
3: hydrazine hydrate / ethanol / 16 h / Reflux
View Scheme
参考文献
Islam, Mojahidul; Siddiqui, Anees A.
Acta Poloniae Pharmaceutica - Drug Research, 2010 , vol. 67, # 5 p. 555 - 562
反应条件
1: AcOH, Ac2O / 2 h / Heating
2: AlCl3 / 2 h / Heating
View Scheme
参考文献
Hashem, A. I.; Shaban, M. E.; El-Kafrawy, A. F.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, p. 763 - 764
反应条件
acetic anhydride; triethylamine
Reflux;
参考文献
Alam; Husain, Asif; Hasan; Suruchi; Anwer
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2636 - 2642
反应条件
1: 94 percent / KOH, hydrazine hydrate / bis-(2-hydroxy-ethyl) ether / 4.5 h / 120 - 190 °C
2: SOCl2 / CHCl3 / 8 h / Heating
3: conc. NH4OH / toluene
4: 72 percent / LiAlH4 / diethyl ether / 4 h / 25 °C
View Scheme
参考文献
El-Fehail Ali; Dandridge; Gleason; et al.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 947 - 952
