3,4-二甲氧基肉桂酰氯合成路线 （共 14 条）
反应条件
thionyl chloride in toluene T=75°C; 16 h;
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
1: pyridine; piperidine 2: thionyl chloride; N,N-dimethylformamide / 1,2-dichloro-ethane / 6 h / Heating View Scheme
参考文献
Vedernikov, Artem I.; Gromov, Sergey P.
Synthesis, 2001 , # 6 p. 889 - 892
反应条件
1: 78.8 percent / NaOH / H2O / 3.5 h / Heating 2: SOCl2 / benzene / 3 h / Heating View Scheme
参考文献
Li, Ya-Lin; Xu, Wen-Fang
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 19 p. 5171 - 5180
反应条件
sodium azide in water; acetone T=0°C; 1 h;
参考文献
Ramamurthy, B.; Sugumaran, M.
Synthesis, 1987 , # 5 p. 523 - 524
反应条件
hydroxylamine hydrochloride; triethylamine in chloroform 1 h; Ambient temperature; Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2810 - 2819
反应条件
in dichloromethane 3 h; Reflux;
参考文献
Zhang, Zhenghua; Liu, Jinbing; Wu, Fengyan; Zhao, Liangzhong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 6 p. 529 - 534
反应条件
1: 4-(3,4-dimethoxyphenyl)-3-buten-2-one With sodium hexamethyldisilazane in tetrahydrofuran T=-78°C; 0.5 h; 2: 3,4-dimethoxycinnamic acid chloride in tetrahydrofuran T=-78 - 20°C; 12 h;
参考文献
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION; LI, Pui-Kai; LI, Chenglong; LIN, Jiayuh; FUCHS, James, R.
Patent: WO2010/121007 A1, 2010 ;
Location in patent: Page/Page column 6; 17-18 ;
反应条件
1.1: pyridine / dichloromethane / 24 h / 20 °C 2.1: acetonitrile / |Microwave irradiation 2.2: 5 h / 160 °C / |Microwave irradiation View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
反应条件
in dichloromethane 3 h; Reflux;
参考文献
Zhang, Zhenghua; Liu, Jinbing; Wu, Fengyan; Zhao, Liangzhong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 6 p. 529 - 534
反应条件
1.1: pyridine / dichloromethane / 24 h / 20 °C 2.1: acetonitrile / |Microwave irradiation 2.2: 5 h / 160 °C / |Microwave irradiation 3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C View Scheme
参考文献
Joerg, Manuela; Shonberg, Jeremy; Mak, Frankie S.; Miller, Neil D.; Yuriev, Elizabeth; Scammells, Peter J.; Capuano, Ben
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 11 p. 3427 - 3433
