4-氨基-3-硝基苯甲酸甲酯合成路线 （共 16 条）
反应条件
thionyl chloride T=20°C; 16 h; Heating / reflux;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/40148 A1, 2006 ;
Location in patent: Page/Page column 19-20 ;
WO 2006/040148 A1
反应条件
sulfuric acid in methanol; anhydrous xylene; water
参考文献
Ciba Specialty Chemicals Corporation
Patent: US6166218 A1, 2000 ;
反应条件
iron(II) sulfate in dimethyl sulfoxide T=20°C; 1 h;
参考文献
Porcal, Williams; Hernandez, Paola; Boiani, Lucia; Boiani, Mariana; Ferreira, Ana; Chidichimo, Agustina; Cazzulo, Juan J.; Olea-Azar, Claudio; Gonzalez, Mercedes; Cerecetto, Hugo
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 14 p. 6995 - 7004
反应条件
potassium tert-butylate; N,N-tetramethylene-thiocarbamoyl-sulphenamide in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Makosza, Mieczyslaw; Bialecki, Maciej
Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 4878 - 4888
反应条件
N,N-tetramethylene-thiocarbamoyl-sulphenamide in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Makosza, Mieczyslaw; Bialecki, Maciej
Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 4878 - 4888
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Makosza, Mieczyslaw; Bialecki, Maciej
Journal of Organic Chemistry, 1998 , vol. 63, # 15 p. 4878 - 4888
反应条件
platinum on activated charcoal; ethyl acetate Hydrogenation;
参考文献
Naim, S. Shawkat; Singh, Sudhir K.; Sharma, Satyavan; Gupta, Suman; Fatma, N.; et al.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 1106 - 1109
反应条件
bromine in dichloromethane Heating;
参考文献
Charrier, Nicolas; Demont, Emmanuel; Dunsdon, Rachel; Maile, Graham; Naylor, Alan; O'Brien, Alistair; Redshaw, Sally; Theobald, Pam; Vesey, David; Walter, Daryl
Synlett, 2005 , # 20 art. no. D23305ST, p. 3071 - 3074
反应条件
1: 3-nitro-4-aminobenzoic acid methyl ester With sodium hydroxide; potassium carbonate; tetrabutylammomium bromide in toluene T=40°C; 1 h; 2: dimethyl sulfate in toluene 2 h;
参考文献
SANWA KAGAKU KENKYUSHO CO., LTD.
Patent: EP1595866 A1, 2005 ;
Location in patent: Page/Page column 26 ;
反应条件
1: platinum/charcoal; ethyl acetate / Hydrogenation 2: methanol 3: ethanolic NaOH View Scheme
参考文献
Thomas; Tyler
Journal of the Chemical Society, 1957 , p. 2197,2199
