(E)-1-(2,4,4-三甲基-2-环己烯-1-基)-2-丁烯-1-酮合成路线 （共 3 条）
反应条件
1: 1-(2,4,4-trimethyl-2-cyclohexen-1-yl)-ethanone With ethylmagnesium bromide; N-methylaniline in toluene
T=25°C; 30 h;
2: acetaldehyde in toluene
T=-5°C; 1 h;
3: With toluene-4-sulfonic acid in toluene
Heating;
参考文献
Rangnekar, Dinesh W.; Kulkarni, Vikas S.; Ranade, Prasad V.; Sabnis, Ram W.
Synthetic Communications, 2007 , vol. 37, # 3 p. 425 - 430
反应条件
1.1: 95 percent / hydrogen / Pd/C / ethanol / 1 h / 20 °C / 2585.74 Torr
2.1: p-toluenesulfonic acid / toluene / 2 h / Heating
2.2: zinc chloride / 3 h / 20 - 70 °C
3.1: ethyl magnesium bromide; monomethyl aniline / toluene / 30 h / 25 °C
3.2: toluene / 1 h / -5 °C
3.3: 65 percent / p-toluenesulfonic acid / toluene / Heating
View Scheme
参考文献
Rangnekar, Dinesh W.; Kulkarni, Vikas S.; Ranade, Prasad V.; Sabnis, Ram W.
Synthetic Communications, 2007 , vol. 37, # 3 p. 425 - 430
反应条件
1.1: p-toluenesulfonic acid / toluene / 2 h / Heating
1.2: zinc chloride / 3 h / 20 - 70 °C
2.1: ethyl magnesium bromide; monomethyl aniline / toluene / 30 h / 25 °C
2.2: toluene / 1 h / -5 °C
2.3: 65 percent / p-toluenesulfonic acid / toluene / Heating
View Scheme
参考文献
Rangnekar, Dinesh W.; Kulkarni, Vikas S.; Ranade, Prasad V.; Sabnis, Ram W.
Synthetic Communications, 2007 , vol. 37, # 3 p. 425 - 430
