4-氯苯并呋喃[3,2d]吡啶合成路线 （共 7 条）
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in 1,2-dichloro-ethane Substitution; 1 h; Heating;
参考文献
Showalter, H. D. Hollis; Bridges, Alexander J.; Zhou, Hairong; Sercel, Anthony D.; McMichael, Amy; Fry, David W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5464 - 5474
反应条件
1: 100 percent / K2CO3 / acetone / 24 h / 25 °C 2: 56 percent / NaH / dimethylsulfoxide / 0.17 h / 25 °C 3: 47 percent / 8 h / 135 - 170 °C 4: 93 percent / oxalyl chloride; DMF / 1,2-dichloro-ethane / 1 h / Heating View Scheme
参考文献
Showalter, H. D. Hollis; Bridges, Alexander J.; Zhou, Hairong; Sercel, Anthony D.; McMichael, Amy; Fry, David W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5464 - 5474
反应条件
1: 47 percent / 8 h / 135 - 170 °C 2: 93 percent / oxalyl chloride; DMF / 1,2-dichloro-ethane / 1 h / Heating View Scheme
参考文献
Showalter, H. D. Hollis; Bridges, Alexander J.; Zhou, Hairong; Sercel, Anthony D.; McMichael, Amy; Fry, David W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5464 - 5474
反应条件
1: 56 percent / NaH / dimethylsulfoxide / 0.17 h / 25 °C 2: 47 percent / 8 h / 135 - 170 °C 3: 93 percent / oxalyl chloride; DMF / 1,2-dichloro-ethane / 1 h / Heating View Scheme
参考文献
Showalter, H. D. Hollis; Bridges, Alexander J.; Zhou, Hairong; Sercel, Anthony D.; McMichael, Amy; Fry, David W.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 26 p. 5464 - 5474
反应条件
2: POCl3 View Scheme
参考文献
Sangapure,S.S.; Agasimundin,Y.S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1976 , vol. 14, p. 688 - 691
反应条件
trichlorophosphate 1) ice bath, 30 min, 2) 70 to 80 deg C, 3.5h; Yield given. Multistep reaction;
参考文献
Hirota; Sasaki; Tashima; Nakayama
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 2 p. 263 - 267
反应条件
hydrazine hydrate in methanol
4 h; Heating;
参考文献
Mahajan, S. B.; Sangapure, S. S.; Agasimundin, Y. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 7 p. 596 - 598
