N-甲基-(6ci,7ci,9ci)-2-噻吩羧酰胺合成路线 （共 13 条）
反应条件
1: 96 percent / SOCl2 / 18 h / Heating 2: 97 percent / methanol; tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temperature, 12 h 3: 76 percent / 10 percent aq. HCl / 0.5 h / Ambient temperature View Scheme
参考文献
Barcock, Richard A.; Chadwick, Derek J.; Storr, Richard C.; Fuller, Lance S.; Young, John H.
Tetrahedron, 1994 , vol. 50, # 14 p. 4149 - 4166
反应条件
1: 96 percent / SOCl2 / 18 h / Heating 2: 97 percent / methanol; tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temperature, 12 h 3: 76 percent / 10 percent aq. HCl / 0.5 h / Ambient temperature 4: 97 percent / 10 percent aq. HCl / dioxane / 1 h / Heating 5: SOCl2 / 5 h / Heating View Scheme
参考文献
Barcock, Richard A.; Chadwick, Derek J.; Storr, Richard C.; Fuller, Lance S.; Young, John H.
Tetrahedron, 1994 , vol. 50, # 14 p. 4149 - 4166
反应条件
1: 96 percent / SOCl2 / 18 h / Heating 2: 97 percent / methanol; tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temperature, 12 h 3: 76 percent / 10 percent aq. HCl / 0.5 h / Ambient temperature 4: 97 percent / 10 percent aq. HCl / dioxane / 1 h / Heating View Scheme
参考文献
Barcock, Richard A.; Chadwick, Derek J.; Storr, Richard C.; Fuller, Lance S.; Young, John H.
Tetrahedron, 1994 , vol. 50, # 14 p. 4149 - 4166
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Shapiro et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 3725,3726
反应条件
copper(l) chloride in chlorobenzene
T=130°C; 12 h; Schlenk techniqueInert atmosphere;
参考文献
Xia, Qinqin; Liu, Xiaolong; Zhang, Yuejiao; Chen, Chao; Chen, Wanzhi
Organic Letters, 2013 , vol. 15, # 13 p. 3326 - 3329
反应条件
sodium hydroxide; p-toluenesulfonyl chloride in acetone
T=0°C;
参考文献
Conde, Santiago; Corral, Carlos; Lissavetzky, Jaime
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 301 - 304
反应条件
sodium hydroxide in water
12 h;
参考文献
Barcock, Richard A.; Chadwick, Derek J.; Storr, Richard C.; Fuller, Lance S.; Young, John H.
Tetrahedron, 1994 , vol. 50, # 14 p. 4149 - 4166
反应条件
potassium carbonate in tetrahydrofuran
Cooling with ice;
参考文献
Du, Ya; Hyster, Todd K.; Rovis, Tomislav
Chemical Communications, 2011 , vol. 47, # 44 p. 12074 - 12076
反应条件
1: thionyl chloride / 2 h / Reflux
2: potassium carbonate / tetrahydrofuran / Cooling with ice
View Scheme
参考文献
Du, Ya; Hyster, Todd K.; Rovis, Tomislav
Chemical Communications, 2011 , vol. 47, # 44 p. 12074 - 12076
反应条件
in tetrahydrofuran; water
T=20°C; 1 h; Inert atmosphere;
参考文献
Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo
European Journal of Organic Chemistry, 2013 , # 34 p. 7815 - 7822
