N-甲基-(6ci,7ci,9ci)-2-噻吩羧酰胺合成路线 （共 13 条）
反应条件
1: hydroxylamine hydrochloride, pyridine / ethanol / 2 h / Heating
2: 87 percent / aq. NaOH, p-toluene sulfonyl chloride / acetone / 0 °C
View Scheme
参考文献
Conde, Santiago; Corral, Carlos; Lissavetzky, Jaime
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 301 - 304
反应条件
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetonitrile
0.0833333 h; Inert atmosphere;
2: With triethylamine in acetonitrile
1.5 h; Inert atmosphere;
参考文献
Hyster, Todd K.; Rovis, Tomislav
Journal of the American Chemical Society, 2010 , vol. 132, # 30 p. 10565 - 10569
反应条件
1: 96 percent / SOCl2 / 18 h / Heating
2: 97 percent / methanol; tetrahydrofuran / 1.) 0 deg C, 0.5 h, 2.) room temperature, 12 h
3: 76 percent / 10 percent aq. HCl / 0.5 h / Ambient temperature
4: 97 percent / 10 percent aq. HCl / dioxane / 1 h / Heating
5: SOCl2 / 5 h / Heating
6: 95 percent / Et3N / CH2Cl2 / 12 h / Heating
View Scheme
参考文献
Barcock, Richard A.; Chadwick, Derek J.; Storr, Richard C.; Fuller, Lance S.; Young, John H.
Tetrahedron, 1994 , vol. 50, # 14 p. 4149 - 4166
