(4-甲氧基苯乙炔基)三甲基硅烷合成路线 （共 73 条）
反应条件
copper trifluoromethanesulfonate in N,N-dimethyl-formamide T=80°C; 48 h;
参考文献
Tetrahedron Letters, , vol. 39, # 23 p. 4075 - 4078
反应条件
toluene-4-sulfonic acid in ethanol T=120°C; 0.5 h; microwave irradiation;
参考文献
Jacubert, Maud; Provot, Olivier; Peyrat, Jean-Francois; Hamze, Abdallah; Brion, Jean-Daniel; Alami, Mouad
Tetrahedron, 2010 , vol. 66, # 21 p. 3775 - 3787
反应条件
1: carbon monoxide; tri-phenyl-antimony With [bis(acetoxy)iodo]benzene in dichloromethane
T=20°C; 7 h;
2: 2-(4-methoxyphenyl)-1-trimethylsilyl-ethyne With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; copper(l) iodide in acetonitrile
T=50°C; 5 h; Further stages.;
参考文献
Kang, Suk-Ku; Ryu, Hyung-Chul; Hong, Young-Taek
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 7 p. 736 - 739
反应条件
KOC(O)Ph; triphenylphosphine; copper(l) chloride in 1,3-dimethyl-imidazolidin-2-one
T=120°C; Sila-Sonogashira-Hagihara cross-coupling reaction; 12 h; Inert atmosphere;
参考文献
Ihara, Hideki; Ueda, Akinori; Suginome, Michinori
Chemistry Letters, 2011 , vol. 40, # 9 p. 972 - 974
反应条件
1: 95 percent / KOH
View Scheme
参考文献
Al-Hassan, Mohammed I.
Journal of Organometallic Chemistry, 1990 , vol. 395, # 2 p. 227 - 229
反应条件
(4R,5R)-DIOP; palladium diacetate; copper(l) chloride in N,N-dimethyl-formamide
T=20 - 120°C; Sila-Sonogashira cross-coupling reaction;
参考文献
Nishihara, Yasushi; Inoue, Eiji; Noyori, Shintaro; Ogawa, Daisuke; Okada, Yoshiaki; Iwasaki, Masayuki; Takagi, Kentaro
Tetrahedron, 2012 , vol. 68, # 24 p. 4869 - 4881
反应条件
1.1: potassium fluoride; methanol / 2 h / 20 °C
2.1: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 6 h / 20 °C / Inert atmosphere
3.1: boron tribromide / dichloromethane / -20 - 20 °C / Inert atmosphere
3.2: Cooling with ice
View Scheme
参考文献
KENT STATE UNIVERSITY; SUMMA HEALTH SYSTEM
Patent: WO2008/157745 A1, 2008 ;
反应条件
silver nitrate in tetrahydrofuran; water
T=20°C; 28 h; Inert atmosphere;
参考文献
Deng, Gui Sheng; Sun, Teng Fei
Chinese Chemical Letters, 2012 , vol. 23, # 10 p. 1115 - 1118,4
反应条件
1: tri-phenyl-antimony With [bis(acetoxy)iodo]benzene in dichloromethane
T=20°C; 7 h;
2: 2-(4-methoxyphenyl)-1-trimethylsilyl-ethyne With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; copper(l) iodide in acetonitrile
T=50°C; 5 h; Further stages.;
参考文献
Kang, Suk-Ku; Ryu, Hyung-Chul; Hong, Young-Taek
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 7 p. 736 - 739
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride in N,N-dimethyl-formamide
T=80°C; cross-coupling;
参考文献
Nishihara, Yasushi; Ikegashira, Kazutaka; Hirabayashi, Kazunori; Ando, Jun-Ichi; Mori, Atsunori; Hiyama, Tamejiro
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1780 - 1787
