(4-甲氧基苯乙炔基)三甲基硅烷合成路线 （共 73 条）
反应条件
1: sodium methylate; potassium carbonate / dichloromethane / 2 h / 20 °C / Inert atmosphere
2: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); diethylamine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Puenner, Florian; Hilt, Gerhard
Chemical Communications, 2012 , vol. 48, # 30 p. 3617 - 3619
反应条件
KOC(O)Ph; triphenylphosphine; copper(l) chloride in 1,3-dimethyl-imidazolidin-2-one
T=120°C; Sila-Sonogashira-Hagihara cross-coupling reaction; 12 h; Inert atmosphere;
参考文献
Ihara, Hideki; Ueda, Akinori; Suginome, Michinori
Chemistry Letters, 2011 , vol. 40, # 9 p. 972 - 974
反应条件
(4R,5R)-DIOP; palladium diacetate; copper(l) chloride in N,N-dimethyl-formamide
T=20 - 120°C; Sila-Sonogashira cross-coupling reaction;
参考文献
Nishihara, Yasushi; Inoue, Eiji; Noyori, Shintaro; Ogawa, Daisuke; Okada, Yoshiaki; Iwasaki, Masayuki; Takagi, Kentaro
Tetrahedron, 2012 , vol. 68, # 24 p. 4869 - 4881
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine in water; N,N-dimethyl-formamide
T=120°C; 0.25 h; Microwave irradiation;
参考文献
Hou, Duen-Ren; Kuan, Ting-Chun; Li, Yu-Kai; Lee, Richmond; Huang, Kuo-Wei
Tetrahedron, 2010 , vol. 66, # 48 p. 9415 - 9420
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
Nishihara, Yasushi; Ikegashira, Kazutaka; Hirabayashi, Kazunori; Ando, Jun-Ichi; Mori, Atsunori; Hiyama, Tamejiro
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1780 - 1787
反应条件
copper(l) iodide; [PdCl2(2,2'-bipyridine)]; cyclohexyl BrettPhos in N,N-dimethyl-formamide
T=150°C; 24 h;
参考文献
Nishihara, Yasushi; Ogawa, Daisuke; Noyori, Shintaro; Iwasaki, Masayuki
Chemistry Letters, 2012 , vol. 41, # 11 p. 1503 - 1505
反应条件
copper(l) iodide; [PdCl2(2,2'-bipyridine)]; cyclohexyl BrettPhos in N,N-dimethyl-formamide
T=120°C; 24 h;
参考文献
Nishihara, Yasushi; Ogawa, Daisuke; Noyori, Shintaro; Iwasaki, Masayuki
Chemistry Letters, 2012 , vol. 41, # 11 p. 1503 - 1505
反应条件
1: potassium carbonate / methanol / |Inert atmosphere
2: [RhCl(η2:η2-cycloocta-1,5-diene)]2; triphenylphosphine / dichloromethane / 40 °C / |Inert atmosphere
View Scheme
参考文献
Xu, Hua-Dong; Zhang, Ren-Wei; Li, Xiaoxun; Huang, Suyu; Tang, Weiping; Hu, Wen-Hao
Organic Letters, 2013 , vol. 15, # 4 p. 840 - 843
反应条件
N-iodo-succinimide; silver nitrate in N,N-dimethyl-formamide
24 h; Darkness;
参考文献
Shi, Yu; Li, Xiaoyu; Liu, Jianhui; Jiang, Wenfeng; Sun, Licheng
Tetrahedron Letters, 2010 , vol. 51, # 28 p. 3626 - 3628
反应条件
1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 °C / |Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 1.5 h / -78 °C / |Inert atmosphere
2.2: 19 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
O'Rourke, Natasha F.; Wulff, Jeremy E.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 8 p. 1292 - 1308
