2,6-二氯-4-(三氟甲基)吡啶合成路线 （共 19 条）
反应条件
trichlorophosphate 10 h; Heating;
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
1: 90 percent / O3 / CH2Cl2; methanol / 24 h / -78 °C 2: 68 percent / 30 percent aq. H2O2; HCOOH / 10 h / 70 °C 3: NH2CONH2 / 8 h / 200 °C 4: 30 percent / POCl3 / 10 h / Heating View Scheme
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
1: acetic anhydride / 14 h / |Reflux 2: ammonium hydroxide / water / 20 °C 3: 1.5 h / 220 - 230 °C 4: trichlorophosphate; phosphorus pentachloride / 8 h / |Reflux View Scheme
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
1: ammonium hydroxide / water / 20 °C 2: 1.5 h / 220 - 230 °C 3: trichlorophosphate; phosphorus pentachloride / 8 h / |Reflux View Scheme
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
trichlorophosphate 10 h; Heating;
参考文献
Jiang, Biao; Xiong, Xen-Nan; Yang, Cai-Guang
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 4 p. 475 - 477
反应条件
1: NH2CONH2 / 8 h / 200 °C 2: 30 percent / POCl3 / 10 h / Heating View Scheme
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
1: 68 percent / 30 percent aq. H2O2; HCOOH / 10 h / 70 °C 2: NH2CONH2 / 8 h / 200 °C 3: 30 percent / POCl3 / 10 h / Heating View Scheme
参考文献
Jiang, Biao; Xiong, Wennan; Zhang, Xiaobing; Zhang, Fangjiang
Organic Process Research and Development, 2001 , vol. 5, # 5 p. 531 - 534
反应条件
ammonia in water T=180°C; 3 h;
参考文献
WO2009/27283 A1, ;
Page/Page column 58-59 ;
反应条件
1: 4-trifluoromethyl-2,6-dichloropyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: carbon dioxide in tetrahydrofuran; hexane T=-78 - 0°C;
参考文献
Tsuzuki, Yasunori; Tomita, Kyoji; Shibamori, Koh-Ichiro; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 2097 - 2109
反应条件
1: With ammonia in water T=150°C; 15 h; autoclave; 2: With hydrogen; 5 palladium on charcoal in water T=100°C; P=13501.4 Torr; 3 h;
参考文献
Ishihara Sangyo Kaisha, Ltd.
Patent: EP2527327 A1, 2012 ;
Location in patent: Page/Page column 6-7 ;
