2,6-二氯-4-(三氟甲基)吡啶合成路线 （共 19 条）
反应条件
ammonia; copper in water T=140°C; 48 h;
参考文献
Haap, Wolfgang; Hebeisen, Paul; Kitas, Eric A.; Kuhn, Bernd; Mohr, Peter; Wessel, Hans Peter
Patent: US2009/143439 A1, 2009 ;
Location in patent: Page/Page column 30 ;
US 20090143439 A1
反应条件
hydrogen iodide; sodium iodide 24 h; Heating; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 51, # 6 p. 953 - 954
反应条件
1: With hydrogen bromide; acetic acid 8 h; Heating / reflux; 2: With sodium hydroxide; water T=0 - 20°C;
参考文献
ISHIHARA SANGYO KAISHA, LTD.
Patent: EP2030971 A1, 2009 ;
Location in patent: Page/Page column 20 ;
反应条件
hydrogen iodide; sodium iodide 24 h; Heating; Title compound not separated from byproducts;
参考文献
Newkome, George R.; Moorfield, Charles N.; Sabbaghian, Bahman
Journal of Organic Chemistry, 1986 , vol. 51, # 6 p. 953 - 954
反应条件
1: With ammonia in water T=150°C; 15 h; autoclave; 2: With hydrogen; 5 palladium on charcoal in water T=100°C; P=13501.4 Torr; 3 h;
参考文献
EP2527327 A1, ;
Page/Page column 6-7 ;
反应条件
1: With ammonia in tetrahydrofuran; water T=150°C; 6 h; autoclave; 2: With hydrogen; 5 palladium on charcoal in tetrahydrofuran; water T=100°C; P=15001.5 Torr; 3 h; Product distribution / selectivity;
参考文献
EP2527327 A1, ;
Page/Page column 7 ;
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C 1.2: tetrahydrofuran; hexane / -78 - 0 °C 2.1: SOCl2 / 3 h / Heating View Scheme
参考文献
Dainippon Pharmaceutical Co., Ltd.
Patent: US5817669 A1, 1998 ;
反应条件
anhydrous iron chloride in tetrahydrofuran T=20°C; 2 h; Inert atmosphere;
参考文献
ISHIHARA SANGYO KAISHA, LTD.
Patent: US2012/35372 A1, 2012 ;
Location in patent: Page/Page column 3-4 ;
反应条件
iron(II) chloride in tetrahydrofuran T=20°C; 2 h; Inert atmosphere; Product distribution / selectivity;
参考文献
ISHIHARA SANGYO KAISHA, LTD.
Patent: US2012/35372 A1, 2012 ;
Location in patent: Page/Page column 4 ;
