2-氟-5-(羟甲基)吡啶合成路线 （共 5 条）
反应条件
1: With thionyl chloride; N,N-dimethyl-formamide in benzene 3 h; Heating / reflux; 2: With sodium tetrahydroborate in 1,4-dioxane T=20°C; 24 h;
参考文献
French, Jarrod B.; Cen, Yana; Vrablik, Tracy L.; Xu, Ping; Allen, Eleanor; Hanna-Rose, Wendy; Sauve, Anthony A.
Biochemistry, 2010 , vol. 49, # 49 p. 10421 - 10439
反应条件
methanol; sodium tetrahydroborate 1 h; Cooling with ice;
参考文献
MSD K.K.
Patent: US2012/22078 A1, 2012 ;
Location in patent: Page/Page column 10 ;
反应条件
potassium carbonate in water Hydrolysis; Heating;
参考文献
Pesti; Huhn; Yin; Xing; Fortunak; Earl
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7718 - 7722
反应条件
1: 53 percent / N-chlorosuccinimide; benzoyl peroxide; HCl / acetonitrile; acetic acid / Heating 2: potassium carbonate / H2O / Heating View Scheme
参考文献
Pesti; Huhn; Yin; Xing; Fortunak; Earl
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7718 - 7722
反应条件
acetic anhydride; sodium nitrite T=0°C;
参考文献
French, Jarrod B.; Cen, Yana; Vrablik, Tracy L.; Xu, Ping; Allen, Eleanor; Hanna-Rose, Wendy; Sauve, Anthony A.
Biochemistry, 2010 , vol. 49, # 49 p. 10421 - 10439
