(6-氯-吡啶3-基)乙酸合成路线 （共 10 条）
反应条件
hydrogenchloride; water T=80°C; 24 h;
参考文献
DOW AGROSCIENCES LLC
Patent: WO2004/57960 A2, 2004 ;
Location in patent: Page 16-17 ;
反应条件
1: ethanol; H2O / 10 h / Heating 2: sulphuric acid / H2O / 3 h / Heating View Scheme
参考文献
Holla, B. Shivarama; Prasanna; Poojary, Boja; Rao; Shridhara; Bhat, U. Ganesha
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 4 p. 864 - 868
参考文献
Leivers, Martin; Miller, John
Patent: US2011/52534 A1, 2011 ;
Location in patent: Page/Page column 90 ;
反应条件
in methanol; hexanes; ethyl acetate
参考文献
DOW AGROSCIENCES LLC
Patent: WO2004/57960 A2, 2004 ;
Location in patent: Page 13-14 ;
反应条件
sulfuric acid in 1,2-dichloro-ethane 5 h; Heating;
参考文献
Holla, B. Shivarama; Prasanna; Poojary, Boja; Rao; Shridhara; Bhat, U. Ganesha
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 4 p. 864 - 868
反应条件
thionyl chloride in methanol
参考文献
US2014/142081 A1, ;
Page/Page column ;
反应条件
hydrogenchloride; sodium iodide in water; acetonitrile 48 h; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2008/71646 A1, 2008 ;
Location in patent: Page/Page column 90-91 ;
WO 2008/071646 A1
反应条件
1: EDC monohydrochloride; 4-methyl-morpholine / N,N-dimethyl-formamide / 96 h / 20 °C
2: tetrahydrofuran; diethyl ether / 1 h / 20 °C / |Cooling with ice; |Inert atmosphere
View Scheme
参考文献
TAISHO PHARMACEUTICAL CO., LTD; Kuwada, Takeshi; Yoshinaga, Mitsukane; Ishizaka, Tomoko; Wakasugi, Daisuke; Shirokawa, Shin-ichi; Hattori, Nobutaka; Shimazaki, Youichi; Miyakoshi, Naoki
Patent: US2013/197217 A1, 2013 ;
反应条件
1: With sodium carbonate; palladium 10 on activated carbon in water; isopropyl alcohol
T=65 - 70°C; Suzuki Coupling;
2: With sulfuric acid; water in isopropyl alcohol
参考文献
Hangauer, David G.
Patent: US2006/160800 A1, 2006 ;
Location in patent: Page/Page column 76 ;
US 20060160800 A1
反应条件
1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1 h / 45 °C
1.2: 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/214785 A1, 2012 ;
