(1,2,4)噻唑(1,5-a)吡嗪合成路线 （共 5 条）
反应条件
1: 75 percent / m-chloroperbenzoic acid / CH2Cl2 / 48 h 2: 37 percent / phosphorus oxychloride / 1 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 506 - 511
反应条件
hydrogen; platinum(IV) oxide in 2-methoxy-ethanol 21.5 h;
参考文献
Gruenenthal GmbH
Patent: US2008/153843 A1, 2008 ;
Location in patent: Page/Page column 68 ;
反应条件
1: With PPA
T=90°C; 4 h;
2: With sodium hydrogencarbonate in water
T=0°C;
参考文献
Gruenenthal GmbH
Patent: US2008/153843 A1, 2008 ;
Location in patent: Page/Page column 68 ;
反应条件
1: With hydroxylamine in tetrahydrofuran
1.5 h; Heating;
2: With PPA
T=150°C; 18 h; Further stages.;
参考文献
Kowalchick, Jennifer E.; Leiting, Barbara; Pryor, KellyAnn D.; Marsilio, Frank; Wu, Joseph K.; He, Huaibing; Lyons, Kathryn A.; Eiermann, George J.; Petrov, Aleksandr; Scapin, Giovanna; Patel, Reshma A.; Thornberry, Nancy A.; Weber, Ann E.; Kim, Dooseop
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 21 p. 5934 - 5939
反应条件
1: 75 percent / m-chloroperbenzoic acid / CH2Cl2 / 48 h
2: 37 percent / phosphorus oxychloride / 1 h / Heating
3: 72 percent / hydrazine hydrate
View Scheme
参考文献
Hardy, Christopher R.; Parrick, John
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 506 - 511
