6-氟-2-甲基-1,3-苯并噻唑合成路线 （共 7 条）
反应条件
sodium hydroxide in ethylene glycol T=125°C; 3 h;
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
反应条件
1: With copper(l) iodide; Na2S*9H2O in N,N-dimethyl-formamide
T=80°C; 12 h;
2: With hydrogenchloride in N,N-dimethyl-formamide
T=20°C;
参考文献
Ma, Dawei; Xue, Peng; Jiang, Yongwen; Xie, Siwei; Zhang, Xiaojing; Dong, Jinhua
Angewandte Chemie, International Edition, 2009 , vol. 48, # 23 p. 4222 - 4225
反应条件
1: pyridine / 2 h / 120 °C
2: phosphorus pentasulfide / benzene / 3 h / Heating
3: NaH / toluene / 0.5 h / Heating
View Scheme
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
反应条件
1: phosphorus pentasulfide / benzene / 3 h / Heating
2: NaH / toluene / 0.5 h / Heating
View Scheme
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
反应条件
sodium hydroxide; potassium hexacyanoferrate(III)
参考文献
Kiprianow; Jagupol'skii
Zhurnal Obshchei Khimii, 1950 , vol. 20, p. 2111,2114; engl. Ausg. S. 2187, 2190
反应条件
1: xylene; P2S5
2: K3<Fe(CN)6>; aqueous NaOH
View Scheme
参考文献
Kiprianow; Jagupol'skii
Zhurnal Obshchei Khimii, 1950 , vol. 20, p. 2111,2114; engl. Ausg. S. 2187, 2190
参考文献
Huang, Xian; Tang, Jing
Tetrahedron, 2003 , vol. 59, # 26 p. 4851 - 4856
