4-氨基-3-氟苯酚合成路线

参考文献

DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.
Patent: WO2013/36232 A2, 2013 ;
Location in patent: Paragraph 00220 ;

399-95-14-氨基-3-氟苯酚

757251-39-14-(4-氨基-3-氟苯氧基)-N-甲基吡啶-2-甲酰胺

参考文献

BAYER PHARMA AKTIENGESELLSCHAFT; STIEHL, Juergen; HEILMANN, Werner; LOeGERS, Michael; REHSE, Joachim; GOTTFRIED, Michael; WICHMANN, Saskia
Patent: WO2011/128261 A1, 2011 ;

328-84-73,4-二氯三氟甲苯+

399-95-14-氨基-3-氟苯酚

101463-63-2

参考文献

E. I. Du Pont de Nemours and Company
Patent: US4745113 A1, 1988 ;

399-95-14-氨基-3-氟苯酚

1020172-07-9Rebastinib

参考文献

DECIPHERA PHARMACEUTICALS, LLC; FLYNN, Daniel L.; PETILLO, Peter A.; KAUFMAN, Michael D.
Patent: WO2013/36232 A2, 2013 ;

399-95-14-氨基-3-氟苯酚

367-28-25-氯-2-硝基甲苯

参考文献

Hodgson; Nicholson
Journal of the Chemical Society, 1941 , p. 645

99586-65-94-氯吡啶-2-甲酰胺+

399-95-14-氨基-3-氟苯酚

757251-54-04-(4-氨基-3-氟苯氧基)-2-吡啶羧酰胺

参考文献

Eisai RandD Management Co., Ltd.
Patent: EP2119706 A1, 2009 ;
Location in patent: Page/Page column 44 ;
EP 2119706 A1

399-95-14-氨基-3-氟苯酚+

79-44-7二甲氨基甲酰氯

821765-73-5

参考文献

ORION CORPORATION
Patent: WO2005/794 A1, 2005 ;
Location in patent: Page 61; 62 ;
WO 2005/000794 A1

399-95-14-氨基-3-氟苯酚+

124-63-0甲烷磺酰氯

821765-75-7

参考文献

HYUNDAI PHARM CO., LTD.; YANG, Jin; KIM, Jinwoong; LEE, Hankyu; KIM, Jaehyun; SON, Changmo; LEE, Kyuhwan; CHOI, Hyungho; KIM, Daehoon; CHOI, Hyosun; RHEE, Jaekeol
Patent: WO2013/105753 A1, 2013 ;
Location in patent: Paragraph 172; 173; 174; 175; 176 ;