7-烯丙氧基-4-甲基香豆素合成路线 （共 21 条）
反应条件
potassium carbonate in acetone
T=60°C; 1 h; regioselective reaction;
参考文献
Zak, Jaroslav; Ron, David; Riva, Elena; Harding, Heather P.; Cross, Benedict C. S.; Baxendale, Ian R.
Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9901 - 9910
参考文献
Thomas C. Elder, Inc.
Patent: US4294847 A1, 1981 ;
反应条件
1: 7-hydroxy-4-methyl-coumarin With sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.25 h;
2: 3-iodoprop-1-ene in N,N-dimethyl-formamide
T=20°C;
参考文献
Aziz-Ur-Rehman; Ilyas, Tehseen; Abbasi, Muhammad Athar; Nafeesa, Khadija; Khaliq, Shaista; Rubab, Kaniz; Hussain, Ghulam; Khurshid, Shazia; Ahmad, Irshad
Asian Journal of Chemistry, 2014 , vol. 26, # 2 p. 326 - 330
参考文献
THE TRUSTEES OF COLLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Patent: WO2006/26368 A2, 2006 ;
Location in patent: Page/Page column 99 ;
反应条件
1: trifluoroacetic acid / 0.5 h / 100 °C / Microwave irradiation
2: potassium carbonate / acetone / 1 h / 60 °C
View Scheme
参考文献
Zak, Jaroslav; Ron, David; Riva, Elena; Harding, Heather P.; Cross, Benedict C. S.; Baxendale, Ian R.
Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9901 - 9910
反应条件
1: decalin / Erhitzen auf Siedetemperatur
2: aqueous NaOH
3: aqueous NaOH
View Scheme
参考文献
Schamschurin
Zhurnal Obshchei Khimii, 1944 , vol. 14, p. 211,213
Chem.Abstr., 1945 , p. 2286
反应条件
in ethylene glycol
Claisen rearrangement; 9 h; Reflux;
参考文献
Litinas, Konstantinos E.; Mangos, Alexandros; Nikkou, Thomas E.; Hadjipavlou-Litina, Dimitra J.
Journal of Enzyme Inhibition and Medicinal Chemistry, 2011 , vol. 26, # 6 p. 805 - 812
反应条件
N,N-diethylaniline
T=218°C;
参考文献
Prashant, Avula; Krupadanam, Gazula Levi David; Srimannarayana, Gutely
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 4 p. 1191 - 1193
反应条件
N,N-diethylaniline
3 h; Heating;
参考文献
Rodighiero; Guiotto; Pastorini; Manzini; Bordin; Baccichetti; Carlassare; Vedaldi; Dall'Acqua
Farmaco, Edizione Scientifica, 1981 , vol. 36, # 7 p. 648 - 662
反应条件
1: 12 percent / diethylaniline / 3 h / Heating
2: 70.9 percent / acetic anhydride / 1 h / Heating
3: 79.8 percent / bromine / acetic acid / 1 h / Ambient temperature
4: 40.7 percent / 4percent KOH / ethanol / 1.33 h / Heating
View Scheme
参考文献
Rodighiero; Guiotto; Pastorini; Manzini; Bordin; Baccichetti; Carlassare; Vedaldi; Dall'Acqua
Farmaco, Edizione Scientifica, 1981 , vol. 36, # 7 p. 648 - 662
