(3,5-二甲基苯基)肼盐酸盐合成路线 （共 4 条）
反应条件
ammonium hydroxide in water
T=25 - 30°C; pH=9.5 - 10;
参考文献
Natco Pharma Limited
Patent: US2010/298351 A1, 2010 ;
Location in patent: Page/Page column 31-32 ;
US 20100298351 A1
反应条件
potassium phosphate; copper(l) iodide; hydrazine hydrate
T=120°C; 6 h; Sealed tubeInert atmosphere;
参考文献
Chen, Junmin; Zhang, Yimin; Hao, Wenyan; Zhang, Rongli; Yi, Fei
Tetrahedron, 2013 , vol. 69, # 2 p. 613 - 617
反应条件
1: With hydrogenchloride; sodium nitrite
T=-10°C; 0.5 h;
2: With hydrogenchloride; tin(ll) chloride
T=4°C;
参考文献
Lagoja, Irene M.; Pannecouque, Christophe; Van Aerschot, Arthur; Witvrouw, Myriam; Debyser, Zeger; Balzarini, Jan; Herdewijn, Piet; De Clercq, Erik
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1546 - 1553
参考文献
Nagarajan, K.; Talwalker, P.K.; Kulkarni, C.L.; Venkateswarlu, A.; Prabhu, S.S.; Nayak, G.V.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 12 p. 1243 - 1257
