hydrogen bromide

1: NaH / tetrahydrofuran / 0 - 25 °C 2: α-chymotrypsin / dimethylsulfoxide; H2O / 22 - 25 °C / potassium phosphate ( pH 7.0); with pig liver esterase the reaction rate is higher but the e.e. is lower 3: 1.) acyl azide formation, 2.) Curtius rearrangement View Scheme

1: α-chymotrypsin / dimethylsulfoxide; H2O / 22 - 25 °C / potassium phosphate ( pH 7.0); with pig liver esterase the reaction rate is higher but the e.e. is lower 2: 1.) acyl azide formation, 2.) Curtius rearrangement View Scheme

1: (i) Na, benzene, (ii) /BRN= 4145678/ 2: KOH / aq. ethanol / Heating 3: aq. HCl / Heating View Scheme

in various solvent(s) Ambient temperatureCandida lipolythica lipase (active component: Candida lypolythica esterase); Yield given. Yields of byproduct given;

hydrogenchloride Heating;

1.) acyl azide formation, 2.) Curtius rearrangement; Yield given. Multistep reaction;