2,6-二甲基-4-氰基吡啶合成路线 （共 16 条）
反应条件
pyridine; trifluoroacetic anhydride in dichloromethane T=0°C; 24 h;
参考文献
Bolli, Martin; Lescop, Gyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat
Patent: US2011/46170 A1, 2011 ;
Location in patent: Page/Page column 20 ;
反应条件
in water T=20°C; 48 h;
参考文献
CYCLACEL LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED
Patent: WO2008/122767 A2, 2008 ;
Location in patent: Page/Page column 60-61 ;
反应条件
1: 2,6-dimethylpyridine N-oxide With dimethyl sulfate 1 h; 2: potassium cyanide in water 48 h;
参考文献
DOV PHARMACEUTICAL, INC.
Patent: WO2005/84439 A1, 2005 ;
Location in patent: Page/Page column 31 ;
WO 2005/084439 A1
参考文献
Ochiai; Suzuki
Pharmaceutical Bulletin, 1954 , vol. 2, p. 247
反应条件
1.1: anhydrous tetramethylammonium chloride; trichlorophosphate / 16 h / 130 °C 1.3: pH 7 - 8 2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; 1,4-dioxane / 18 h / 75 °C / Inert atmosphere 3.1: ammonia / methanol / 20 h / 60 °C 4.1: trifluoroacetic anhydride; pyridine / dichloromethane / 24 h / 0 °C View Scheme
参考文献
Bolli, Martin; Lescop, Gyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat
Patent: US2011/46170 A1, 2011 ;
反应条件
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / toluene; 1,4-dioxane / 18 h / 75 °C / Inert atmosphere 2: ammonia / methanol / 20 h / 60 °C 3: trifluoroacetic anhydride; pyridine / dichloromethane / 24 h / 0 °C View Scheme
参考文献
Bolli, Martin; Lescop, Gyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat
Patent: US2011/46170 A1, 2011 ;
反应条件
Cu(NO3)2*3H2O; cesium fluoride in methanol; water T=100°C; 4 h;
参考文献
Liskey, Carl W.; Liao, Xuebin; Hartwig, John F.
Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11389 - 11391
反应条件
in water T=20°C; 24 h;
参考文献
Charier, Sandrine; Ruel, Odile; Baudin, Jean-Bernard; Alcor, Damien; Allemand, Jean-Francois; Meglio, Adrien; Jullien, Ludovic; Valeur, Bernard
Chemistry - A European Journal, 2006 , vol. 12, # 4 p. 1097 - 1113
反应条件
1: ammonia / methanol / 20 h / 60 °C 2: trifluoroacetic anhydride; pyridine / dichloromethane / 24 h / 0 °C View Scheme
参考文献
Bolli, Martin; Lescop, Gyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat
Patent: US2011/46170 A1, 2011 ;
反应条件
methyl iodide Behandeln des Reaktionsprodukts mit KCN in wss. Dioxan;
参考文献
Okamoto; Tani
Chemical and Pharmaceutical Bulletin, 1959 , vol. 7, p. 925,928
Full Text Show Details
Okamoto; Tani
Chemical and Pharmaceutical Bulletin, 1959 , vol. 7, p. 130,925, 929
