5-羟基甲基吡啶-2-羧酸甲酯合成路线 （共 4 条）
反应条件
hydrogen; sodium acetate; palladium dichloride in methanol
T=35°C; P=760.051 Torr; 3 h;
参考文献
Chen, Xi-Bo; Hu, Qiu-Peng; Yuan, Qian-Jia; Ding, Wei; Ren, Jiangmeng; Zeng, Bu-Bing
Tetrahedron Letters, 2012 , vol. 53, # 29 p. 3798 - 3801
反应条件
trifluoroacetic acid in methanol
T=20°C; 72 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; GAVAI, Ashvinikumar V.; ZHAO, Yufen; O'MALLEY, Daniel; QUESNELLE, Claude A.; FINK, Brian E.; NORRIS, Derek J.; HAN, Wen-Ching; DELUCCA, George V.
Patent: WO2014/47374 A1, 2014 ;
Location in patent: Paragraph 00379 ;
反应条件
1: triethylamine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / N,N-dimethyl-formamide / 18.5 h / 75 °C / 2585.81 Torr / |Sealed tube
2: trifluoroacetic acid / methanol / 72 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; GAVAI, Ashvinikumar V.; ZHAO, Yufen; O'MALLEY, Daniel; QUESNELLE, Claude A.; FINK, Brian E.; NORRIS, Derek J.; HAN, Wen-Ching; DELUCCA, George V.
Patent: WO2014/47374 A1, 2014 ;
反应条件
1: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C
2: triethylamine; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / N,N-dimethyl-formamide / 18.5 h / 75 °C / 2585.81 Torr / |Sealed tube
3: trifluoroacetic acid / methanol / 72 h / 20 °C
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; GAVAI, Ashvinikumar V.; ZHAO, Yufen; O'MALLEY, Daniel; QUESNELLE, Claude A.; FINK, Brian E.; NORRIS, Derek J.; HAN, Wen-Ching; DELUCCA, George V.
Patent: WO2014/47374 A1, 2014 ;
