3-氨基噻吩-4-羧酸甲酯盐酸盐合成路线 （共 7 条）
反应条件
MH2OH*HCl in acetonitrile 1 h; Heating;
参考文献
Barker, John M.; Huddleston, Patrick R.; Wood, Michael L.
Synthetic Communications, 2002 , vol. 32, # 16 p. 2565 - 2568
反应条件
hydrogenchloride; methanol in diethyl ether T=20°C; 24 h;
参考文献
AVANIR PHARMACEUTICALS
Patent: WO2006/102191 A1, 2006 ;
Location in patent: Page/Page column 56; 88-89 ;
参考文献
LAILA NUTRACEUTICALS
Patent: US2010/68178 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
1: 24 percent / 5percent aq. Na2CO3 / dioxane / 44 h / Ambient temperature 2: 93 percent / NaOH / aq. ethanol / 1 h / 45 °C View Scheme
参考文献
Norman, Mark H.; Navas III, Frank; Thompson, James B.; Rigdon, Greg C.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 24 p. 4692 - 4703
反应条件
sodium carbonate in 1,4-dioxane 44 h; Ambient temperature;
参考文献
Norman, Mark H.; Navas III, Frank; Thompson, James B.; Rigdon, Greg C.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 24 p. 4692 - 4703
反应条件
sodium acetate in water
T=20 - 55°C; 3.5 h;
参考文献
Shin, Dongwon; Sinkeldam, Renatus W.; Tor, Yitzhak
Journal of the American Chemical Society, 2011 , vol. 133, # 38 p. 14912 - 14915
参考文献
Baker et al.
Journal of Organic Chemistry, 1953 , vol. 18, p. 133,136
